Acetophenone-based linker for solid-phase peptide synthesis

Chinh T. Bui, Andrew M. Bray, Thao Nguyen, Francesca Ercole, Firas Rasoul, Wayne Sampson, N. Joe Maeji

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

A new and cost-effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhase(TM) crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10-20% trifluoroacetic acid (TFA) in dichloromethane (DCM). Solid-phase syntheses of model decapeptides using this linker are described. Copyright (C) 2000 European Peptide Society and John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalJournal of Peptide Science
Volume6
Issue number2
DOIs
Publication statusPublished - Feb 2000
Externally publishedYes

Keywords

  • Acetophenone-based linker
  • Hydroxyethyl polystyrene
  • Solid-phase organic chemistry
  • Solid-phase peptide synthesis

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