A new and cost-effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhase(TM) crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10-20% trifluoroacetic acid (TFA) in dichloromethane (DCM). Solid-phase syntheses of model decapeptides using this linker are described. Copyright (C) 2000 European Peptide Society and John Wiley and Sons, Ltd.
|Number of pages||8|
|Journal||Journal of Peptide Science|
|Publication status||Published - Feb 2000|
- Acetophenone-based linker
- Hydroxyethyl polystyrene
- Solid-phase organic chemistry
- Solid-phase peptide synthesis