ACE2, a new regulator of the renin-angiotensin system.

Louise M Burrell, Colin Ivor Johnston, Chris Tikellis, Mark Emmauel Cooper

Research output: Contribution to journalReview ArticleResearchpeer-review


Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the renin-angiotensin system (RAS). ACE2 is a newly described enzyme identified in rodents and humans with a more restricted distribution than ACE, and is found mainly in heart and kidney. ACE2 cleaves a single residue from angiotensin I (Ang I) to generate Ang 1-9, and degrades Ang II, the main effector of the RAS, to the vasodilator Ang 1-7. The importance of ACE2 in normal physiology and pathophysiological states is largely unknown. ACE2 might act in a counter-regulatory manner to ACE, modulating the balance between vasoconstrictors and vasodilators within the heart and kidney, and playing a significant role in regulating cardiovascular and renal function.
Original languageEnglish
Pages (from-to)166-169
Number of pages3
JournalTrends in Endocrinology & Metabolism
Issue number4
Publication statusPublished - 2004
Externally publishedYes

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