ACE2, a new regulator of the renin-angiotensin system.

Louise M Burrell, Colin Ivor Johnston, Chris Tikellis, Mark Emmauel Cooper

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the renin-angiotensin system (RAS). ACE2 is a newly described enzyme identified in rodents and humans with a more restricted distribution than ACE, and is found mainly in heart and kidney. ACE2 cleaves a single residue from angiotensin I (Ang I) to generate Ang 1-9, and degrades Ang II, the main effector of the RAS, to the vasodilator Ang 1-7. The importance of ACE2 in normal physiology and pathophysiological states is largely unknown. ACE2 might act in a counter-regulatory manner to ACE, modulating the balance between vasoconstrictors and vasodilators within the heart and kidney, and playing a significant role in regulating cardiovascular and renal function.
Original languageEnglish
Pages (from-to)166-169
Number of pages3
JournalTrends in Endocrinology and Metabolism
Volume15
Issue number4
Publication statusPublished - 2004
Externally publishedYes

Cite this

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title = "ACE2, a new regulator of the renin-angiotensin system.",
abstract = "Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the renin-angiotensin system (RAS). ACE2 is a newly described enzyme identified in rodents and humans with a more restricted distribution than ACE, and is found mainly in heart and kidney. ACE2 cleaves a single residue from angiotensin I (Ang I) to generate Ang 1-9, and degrades Ang II, the main effector of the RAS, to the vasodilator Ang 1-7. The importance of ACE2 in normal physiology and pathophysiological states is largely unknown. ACE2 might act in a counter-regulatory manner to ACE, modulating the balance between vasoconstrictors and vasodilators within the heart and kidney, and playing a significant role in regulating cardiovascular and renal function.",
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ACE2, a new regulator of the renin-angiotensin system. / Burrell, Louise M; Johnston, Colin Ivor; Tikellis, Chris; Cooper, Mark Emmauel.

In: Trends in Endocrinology and Metabolism, Vol. 15, No. 4, 2004, p. 166-169.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - ACE2, a new regulator of the renin-angiotensin system.

AU - Burrell, Louise M

AU - Johnston, Colin Ivor

AU - Tikellis, Chris

AU - Cooper, Mark Emmauel

PY - 2004

Y1 - 2004

N2 - Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the renin-angiotensin system (RAS). ACE2 is a newly described enzyme identified in rodents and humans with a more restricted distribution than ACE, and is found mainly in heart and kidney. ACE2 cleaves a single residue from angiotensin I (Ang I) to generate Ang 1-9, and degrades Ang II, the main effector of the RAS, to the vasodilator Ang 1-7. The importance of ACE2 in normal physiology and pathophysiological states is largely unknown. ACE2 might act in a counter-regulatory manner to ACE, modulating the balance between vasoconstrictors and vasodilators within the heart and kidney, and playing a significant role in regulating cardiovascular and renal function.

AB - Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the renin-angiotensin system (RAS). ACE2 is a newly described enzyme identified in rodents and humans with a more restricted distribution than ACE, and is found mainly in heart and kidney. ACE2 cleaves a single residue from angiotensin I (Ang I) to generate Ang 1-9, and degrades Ang II, the main effector of the RAS, to the vasodilator Ang 1-7. The importance of ACE2 in normal physiology and pathophysiological states is largely unknown. ACE2 might act in a counter-regulatory manner to ACE, modulating the balance between vasoconstrictors and vasodilators within the heart and kidney, and playing a significant role in regulating cardiovascular and renal function.

M3 - Review Article

VL - 15

SP - 166

EP - 169

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 4

ER -