ACE inhibition salvages the visual loss caused by diabetes

Bang V Bui, James A Armitage, Mary Tolcos, M E Cooper, Algis J Vingrys

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Abstract

AIMS: We consider the nature of retinal dysfunction in streptozotocin rats and assess the functional benefits of administering an angiotensin enzyme inhibitor or an inhibitor of advanced glycation end product formation. METHODS: Sprague-Dawley rats (n=44) were randomly assigned to control (C=12, C(p)=4, C(a)=4) and diabetic groups (Streptozotocin, D=24). Diabetes was diagnosed based on a range of physiological and biochemical parameters at 4, 8 and 12 weeks. Streptozotocin animals were administered insulin daily (4 units protophane). Animals were treated with either an Angiotensin Converting Enzyme inhibitor (perindopril, C(p)=4, D(p)=8) or an inhibitor of advanced glycation end product formation (aminoguanidine, C(a)=4, D(a)=8). Dark-adapted electroretinograms were measured on anaesthetized animals at 12 weeks following streptozotocin treatment. Photoreceptoral and inner retinal responses were extracted, modelled and compared using ANOVA. RESULTS: Streptozotocin injection increased blood glucose, glycosylated haemoglobin, fluid intake and urine volume, whereas body weight was decreased. Perindopril treatment produced improvements (p
Original languageEnglish
Pages (from-to)401 - 408
Number of pages8
JournalDiabetologia
Volume46
Issue number3
Publication statusPublished - 2003

Cite this

Bui, B. V., Armitage, J. A., Tolcos, M., Cooper, M. E., & Vingrys, A. J. (2003). ACE inhibition salvages the visual loss caused by diabetes. Diabetologia, 46(3), 401 - 408.