Accuracy of the Securetec DrugWipe 6s Ketamine device in detecting acute and residual salivary ketamine following a stepwise intravenous treatment protocol

Amie C. Hayley, Maja Green, Michael Keane, Panagiota Kostakis, Yahya Shehabi, Con K.K. Stough, Luke A. Downey

Research output: Contribution to journalArticleResearchpeer-review

Abstract

To evaluate the sensitivity of the Securetec DrugWipe 6 S Ketamine device in detecting salivary ketamine, we administered three fixed, increasing sub-anaesthetic doses of intravenous ketamine solution to 20 participants using an open-label, within subjects’ protocol. Results indicated, at a cut-off level of 5 ng/mL for ketamine in oral fluid, the Securetec DrugWipe 6 S Ketamine device indicated a uniformly positive result for the presence of ketamine during the acute dosing phase where corresponding mean whole blood ketamine concentrations were 0.38 mg/L (dose 1), 0.48 mg/L (dose 2) and 0.82 mg/L (dose 3), respectively. At 2-hours post treatment, the positive detection rate was 85% where corresponding mean whole blood concentrations of ketamine were 0.21 mg/L. Device detection rate reduced to 40% at 4-hours post-treatment.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalCanadian Society of Forensic Science Journal
Volume53
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • blood
  • Ketamine
  • Kétamine
  • liquide buccal
  • oral fluid
  • saliva
  • salive
  • sang
  • Securetec DrugWipe 6 S Ketamine
  • Securetec DrugWipe 6S Ketamine

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