Accelerating the search for the missing proteins in the human proteome

Mark S. Baker, Seong Beom Ahn, Abidali Mohamedali, Mohammad T. Islam, David Cantor, Peter D. Verhaert, Susan Fanayan, Samridhi Sharma, Edouard C. Nice, Mark Connor, Shoba Ranganathan

Research output: Contribution to journalReview ArticleResearchpeer-review

57 Citations (Scopus)

Abstract

The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, B18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins.

Original languageEnglish
Article number14271
Number of pages13
JournalNature Communications
Volume8
DOIs
Publication statusPublished - 24 Jan 2017

Keywords

  • mass spectrometry
  • proteome
  • proteomics

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