Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients

Bernadette Meller, Louise Cullen, William A Parsonage, Jaimi Greenslade, Sally J Aldous, Tobias Reichlin, Karin Wildi, Raphael Twerenbold, Cedric Jaeger, Petra Hillinger, Philip Haaf, Christian Puelacher, Vera Kern, Katharina Rentsch, Fabio Stallone, Maria Rubini Gimenez, Paola Ballarino, Stefano Bassetti, Astrid Walukiewicz, Richard W TroughtonChristopher Pemberton, A Mark Richards, Kevin Chu, Christopher Michael Reid, Martin Than, Christian Mueller

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Abstract

Background: We aimed to evaluate the efficacy and safety of using high-sensitivity cardiac troponin T (hs-cTnT) within an accelerated diagnostic protocol (ADP) in patients presenting with symptoms suggestive of acute myocardial infarction (AMI) for rapid rule-out of AMI. Methods: In two independent large multicenter studies, levels of hs-cTnT at presentation and at 2 h were combined with the Throm bolysis In Myocardial Infarction (TIMI) risk score and ECG findings. The ADP defined patients with normal levels of hs-cTnT at presentation and 2 h, a TIMI score =1, and normal ECG findings as candidates for rapid rule-out of AMI and rapid discharge. Major adverse cardiac events (MACEs) occurring within 30-days were centrally adjudicated by two independent cardiologists. Results: In the derivation cohort, among 1085 consecutive patients 198 patients (18.2 ) had a MACE. The ADP classified 374 patients (34.5 ) as low-risk. None of these patients had a MACE at 30 days, resulting in a negative predictive value (NPV) of 100 (95 CI, 99.0-100 ) and a sensitivity of 100 (95 CI, 98.2 -100 ). In the validation cohort, among 1590 consecutive patients 231 patients (14.5 ) had a MACE. The ADP classified 641 patients (40.3 ) as low-risk. 6 of these patients had a MACE at 30 days, resulting in a NPV of 99.1 (95 CI, 98.0-99.6 ) and a sensitivity of 97.4 (95 CI, 94.5-98.8 ). Conclusions: The ADP including hs-cTnT allows early identification 35 to 40 of patients to be at extremely low risk of MACE and therefore ideal candidates for outpatient management.
Original languageEnglish
Pages (from-to)208 - 215
Number of pages8
JournalInternational Journal of Cardiology
Volume184
Issue number1
DOIs
Publication statusPublished - 2015

Cite this

Meller, B., Cullen, L., Parsonage, W. A., Greenslade, J., Aldous, S. J., Reichlin, T., Wildi, K., Twerenbold, R., Jaeger, C., Hillinger, P., Haaf, P., Puelacher, C., Kern, V., Rentsch, K., Stallone, F., Gimenez, M. R., Ballarino, P., Bassetti, S., Walukiewicz, A., ... Mueller, C. (2015). Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients. International Journal of Cardiology, 184(1), 208 - 215. https://doi.org/10.1016/j.ijcard.2015.02.006