Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction

M Jane Black; Kyung Joon Lim; Monika A Zimanyi; Amanda K Sampson; Kristen J Bubb; Rebecca L Flower; Helena C Parkington; Marianne Tare; Katherine M Denton

doi:10.1152/ajpregu.00403.2014

Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction

M Jane Black, Kyung Joon Lim, Monika A Zimanyi, Amanda K Sampson, Kristen J Bubb, Rebecca L Flower, Helena C Parkington, Marianne Tare, Katherine M Denton

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

Abstract

Many studies report sexual dimorphism in the fetal programming of adult disease. We hypothesised that there would be differences in the age-related decline in renal function between male and female intrauterine-growth restricted rats. Early life growth restriction was induced in rat offspring by administering a low protein diet (LPD; 8.7 casein) to dams during pregnancy and lactation. Control dams were fed a normal protein diet (NPD; 20 casein). Mean arterial pressure (MAP) and renal structure and function were assessed in 32 and 100 week old offspring. Mesenteric artery function was examined at 100 weeks using myography. At 3-days of age body weight was 24 lower (P

Original language	English
Pages (from-to)	1153 - 1161
Number of pages	9
Journal	American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume	309
Issue number	9
DOIs	https://doi.org/10.1152/ajpregu.00403.2014
Publication status	Published - 2015

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10.1152/ajpregu.00403.2014

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Black, M. J., Lim, K. J., Zimanyi, M. A., Sampson, A. K., Bubb, K. J., Flower, R. L., Parkington, H. C., Tare, M., & Denton, K. M. (2015). Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 309(9), 1153 - 1161. https://doi.org/10.1152/ajpregu.00403.2014

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title = "Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction",

abstract = "Many studies report sexual dimorphism in the fetal programming of adult disease. We hypothesised that there would be differences in the age-related decline in renal function between male and female intrauterine-growth restricted rats. Early life growth restriction was induced in rat offspring by administering a low protein diet (LPD; 8.7 casein) to dams during pregnancy and lactation. Control dams were fed a normal protein diet (NPD; 20 casein). Mean arterial pressure (MAP) and renal structure and function were assessed in 32 and 100 week old offspring. Mesenteric artery function was examined at 100 weeks using myography. At 3-days of age body weight was 24 lower (P",

author = "Black, {M Jane} and Lim, {Kyung Joon} and Zimanyi, {Monika A} and Sampson, {Amanda K} and Bubb, {Kristen J} and Flower, {Rebecca L} and Parkington, {Helena C} and Marianne Tare and Denton, {Katherine M}",

year = "2015",

doi = "10.1152/ajpregu.00403.2014",

language = "English",

volume = "309",

pages = "1153 -- 1161",

journal = "American Journal of Physiology - Regulatory Integrative and Comparative Physiology",

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publisher = "American Physiological Society",

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Black, MJ, Lim, KJ, Zimanyi, MA, Sampson, AK, Bubb, KJ, Flower, RL, Parkington, HC , Tare, M & Denton, KM 2015, 'Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 309, no. 9, pp. 1153 - 1161. https://doi.org/10.1152/ajpregu.00403.2014

Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction. / Black, M Jane; Lim, Kyung Joon; Zimanyi, Monika A et al.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 309, No. 9, 2015, p. 1153 - 1161.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction

AU - Black, M Jane

AU - Lim, Kyung Joon

AU - Zimanyi, Monika A

AU - Sampson, Amanda K

AU - Bubb, Kristen J

AU - Flower, Rebecca L

AU - Parkington, Helena C

AU - Tare, Marianne

AU - Denton, Katherine M

PY - 2015

Y1 - 2015

N2 - Many studies report sexual dimorphism in the fetal programming of adult disease. We hypothesised that there would be differences in the age-related decline in renal function between male and female intrauterine-growth restricted rats. Early life growth restriction was induced in rat offspring by administering a low protein diet (LPD; 8.7 casein) to dams during pregnancy and lactation. Control dams were fed a normal protein diet (NPD; 20 casein). Mean arterial pressure (MAP) and renal structure and function were assessed in 32 and 100 week old offspring. Mesenteric artery function was examined at 100 weeks using myography. At 3-days of age body weight was 24 lower (P

AB - Many studies report sexual dimorphism in the fetal programming of adult disease. We hypothesised that there would be differences in the age-related decline in renal function between male and female intrauterine-growth restricted rats. Early life growth restriction was induced in rat offspring by administering a low protein diet (LPD; 8.7 casein) to dams during pregnancy and lactation. Control dams were fed a normal protein diet (NPD; 20 casein). Mean arterial pressure (MAP) and renal structure and function were assessed in 32 and 100 week old offspring. Mesenteric artery function was examined at 100 weeks using myography. At 3-days of age body weight was 24 lower (P

UR - http://ajpregu.physiology.org/content/ajpregu/309/9/R1153.full.pdf

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DO - 10.1152/ajpregu.00403.2014

M3 - Article

SN - 1522-1490

VL - 309

SP - 1153

EP - 1161

JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

IS - 9

ER -

Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction

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Consequences of elevated maternal glucocorticoids for early childhood renal development and function

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Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction

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Consequences of elevated maternal glucocorticoids for early childhood renal development and function

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