Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction

M Jane Black, Kyung Joon Lim, Monika A Zimanyi, Amanda K Sampson, Kristen J Bubb, Rebecca L Flower, Helena C Parkington, Marianne Tare, Katherine M Denton

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Many studies report sexual dimorphism in the fetal programming of adult disease. We hypothesised that there would be differences in the age-related decline in renal function between male and female intrauterine-growth restricted rats. Early life growth restriction was induced in rat offspring by administering a low protein diet (LPD; 8.7 casein) to dams during pregnancy and lactation. Control dams were fed a normal protein diet (NPD; 20 casein). Mean arterial pressure (MAP) and renal structure and function were assessed in 32 and 100 week old offspring. Mesenteric artery function was examined at 100 weeks using myography. At 3-days of age body weight was 24 lower (P
Original languageEnglish
Pages (from-to)1153 - 1161
Number of pages9
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume309
Issue number9
DOIs
Publication statusPublished - 2015

Cite this

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title = "Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction",
abstract = "Many studies report sexual dimorphism in the fetal programming of adult disease. We hypothesised that there would be differences in the age-related decline in renal function between male and female intrauterine-growth restricted rats. Early life growth restriction was induced in rat offspring by administering a low protein diet (LPD; 8.7 casein) to dams during pregnancy and lactation. Control dams were fed a normal protein diet (NPD; 20 casein). Mean arterial pressure (MAP) and renal structure and function were assessed in 32 and 100 week old offspring. Mesenteric artery function was examined at 100 weeks using myography. At 3-days of age body weight was 24 lower (P",
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Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction. / Black, M Jane; Lim, Kyung Joon; Zimanyi, Monika A; Sampson, Amanda K; Bubb, Kristen J; Flower, Rebecca L; Parkington, Helena C; Tare, Marianne; Denton, Katherine M.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 309, No. 9, 2015, p. 1153 - 1161.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction

AU - Black, M Jane

AU - Lim, Kyung Joon

AU - Zimanyi, Monika A

AU - Sampson, Amanda K

AU - Bubb, Kristen J

AU - Flower, Rebecca L

AU - Parkington, Helena C

AU - Tare, Marianne

AU - Denton, Katherine M

PY - 2015

Y1 - 2015

N2 - Many studies report sexual dimorphism in the fetal programming of adult disease. We hypothesised that there would be differences in the age-related decline in renal function between male and female intrauterine-growth restricted rats. Early life growth restriction was induced in rat offspring by administering a low protein diet (LPD; 8.7 casein) to dams during pregnancy and lactation. Control dams were fed a normal protein diet (NPD; 20 casein). Mean arterial pressure (MAP) and renal structure and function were assessed in 32 and 100 week old offspring. Mesenteric artery function was examined at 100 weeks using myography. At 3-days of age body weight was 24 lower (P

AB - Many studies report sexual dimorphism in the fetal programming of adult disease. We hypothesised that there would be differences in the age-related decline in renal function between male and female intrauterine-growth restricted rats. Early life growth restriction was induced in rat offspring by administering a low protein diet (LPD; 8.7 casein) to dams during pregnancy and lactation. Control dams were fed a normal protein diet (NPD; 20 casein). Mean arterial pressure (MAP) and renal structure and function were assessed in 32 and 100 week old offspring. Mesenteric artery function was examined at 100 weeks using myography. At 3-days of age body weight was 24 lower (P

UR - http://ajpregu.physiology.org/content/ajpregu/309/9/R1153.full.pdf

U2 - 10.1152/ajpregu.00403.2014

DO - 10.1152/ajpregu.00403.2014

M3 - Article

VL - 309

SP - 1153

EP - 1161

JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

SN - 1522-1490

IS - 9

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