Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction

M Jane Black, Kyung Joon Lim, Monika A Zimanyi, Amanda K Sampson, Kristen J Bubb, Rebecca L Flower, Helena C Parkington, Marianne Tare, Katherine M Denton

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Many studies report sexual dimorphism in the fetal programming of adult disease. We hypothesised that there would be differences in the age-related decline in renal function between male and female intrauterine-growth restricted rats. Early life growth restriction was induced in rat offspring by administering a low protein diet (LPD; 8.7 casein) to dams during pregnancy and lactation. Control dams were fed a normal protein diet (NPD; 20 casein). Mean arterial pressure (MAP) and renal structure and function were assessed in 32 and 100 week old offspring. Mesenteric artery function was examined at 100 weeks using myography. At 3-days of age body weight was 24 lower (P
Original languageEnglish
Pages (from-to)1153 - 1161
Number of pages9
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number9
Publication statusPublished - 2015

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