Absorption and isomerization of caffeoylquinic acids from different foods using ileostomist volunteers

T. Erk, M. Renouf, G. Williamson, R. Melcher, H. Steiling, E. Richling

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24 Citations (Scopus)


Background: Polyphenols are thought to play important roles in human nutrition and health but these health effects are dependent on their bioavailability. This study is one of a series with the aim of determining possible effects of food matrices on caffeoylquinic acid (CQA) bioavailability using ileostomy volunteers. Methods: After a CQA-free diet, ileostomists consumed coffee (746 μmol total CQA), and CQAs in excreted ileal fluid were subsequently identified and quantified with HPLC-diode array detection and HPLC-ESI-MS/MS. In our previous studies, other food sources such as cloudy apple juice (CAJ) (358 μmol CQA) and apple smoothie (AS) (335 μmol CQA) were investigated with the same model. Results: Interesterification of CQA from both apple matrices was observed during gastrointestinal passage, whereas CQA consumed in coffee was not influenced by interesterification reactions. In total, 74.3, 22.4, and 23.8 % of the CQA from CAJ, AS, and coffee, respectively, were absorbed or degraded. Conclusion: Our results show that variations in food matrices and variations in phenolic composition have a major influence on intestinal bioavailability and interesterification of the investigated subclass of polyphenols, the CQAs.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalEuropean Journal of Nutrition
Issue number1
Publication statusPublished - 1 Feb 2014
Externally publishedYes


  • Apple juice
  • Apple smoothie
  • Bioavailability
  • Caffeoylquinic acid
  • Coffee
  • Ileostomy

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