Abnormal myelination in the spinal cord of PTPalpha-knockout mice

Quan-Hong Ma, Tao Xiang, Zara Zhuyun Yang, Xu Zhang, Jude Taylor, Zhi-Cheng Xiao

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1 Citation (Scopus)


PTPalpha interacts with F3/contactin to form a membrane-spanning co-receptor complex to transduce extracellular signals to Fyn tyrosine kinase. As both F3 and Fyn regulate myelination, we investigated a role for PTPalpha in this process. Here, we report that both oligodendrocytes and neurons express PTPalpha that evenly distributes along myelinated axons of the spinal cord. The ablation of PTPalpha in vivo leads to early formation of transverse bands that are mainly constituted by F3 and Caspr along the axoglial interface. Notably, PTPalpha deficiency facilitates abnormal myelination and pronouncedly increases the number of non-landed oligodendrocyte loops at shortened paranodes in the spinal cord. Small axons, which are normally less myelinated, have thick myelin sheaths in the spinal cord of PTPalpha-null animals. Thus, PTPalpha may be involved in the formation of axoglial junctions and ensheathment in small axons during myelination of the spinal cord.
Original languageEnglish
Pages (from-to)370 - 376
Number of pages7
JournalCell Adhesion and Migration
Issue number4
Publication statusPublished - 2013

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