TY - JOUR
T1 - Abnormal brain function in neuromyelitis optica
T2 - A fMRI investigation of mPASAT
AU - Wang, Fei
AU - Liu, Yaou
AU - Li, Jianjun
AU - Sondag, Matthew
AU - Law, Meng
AU - Zee, Chi Shing
AU - Dong, Huiqing
AU - Li, Kuncheng
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Purpose Cognitive impairment with the Neuromyelitis Optica (NMO) patients is debated. The present study is to study patterns of brain activation in NMO patients during a pair of task-related fMRI. Materials and methods We studied 20 patients with NMO and 20 control subjects matched for age, gender, education and handedness. All patients with NMO met the 2006 Wingerchuk diagnostic criteria. The fMRI paradigm included an auditory attention monitoring task and a modified version of the Paced Auditory Serial Addition Task (mPASAT). Both tasks were temporally and spatially balanced, with the exception of task difficulty. Results In mPASAT, Activation regions in control subjects included bilateral superior temporal gyri (BA22), left inferior frontal gyrus (BA45), bilateral inferior parietal lobule (BA7), left cingulate gyrus (BA32), left insula (BA13), and cerebellum. Activation regions in NMO patients included bilateral superior temporal gyri (BA22), left inferior frontal gyrus (BA9), right cingulate gyrus (BA32), right inferior parietal gyrus (BA40), left insula (BA13) and cerebellum. Some dispersed cognition related regions are greater in the patients. Conclusions The present study showed altered cerebral activation during mPASAT in patients with NMO relative to healthy controls. These results are speculated to provide further evidence for brain plasticity in patients with NMO.
AB - Purpose Cognitive impairment with the Neuromyelitis Optica (NMO) patients is debated. The present study is to study patterns of brain activation in NMO patients during a pair of task-related fMRI. Materials and methods We studied 20 patients with NMO and 20 control subjects matched for age, gender, education and handedness. All patients with NMO met the 2006 Wingerchuk diagnostic criteria. The fMRI paradigm included an auditory attention monitoring task and a modified version of the Paced Auditory Serial Addition Task (mPASAT). Both tasks were temporally and spatially balanced, with the exception of task difficulty. Results In mPASAT, Activation regions in control subjects included bilateral superior temporal gyri (BA22), left inferior frontal gyrus (BA45), bilateral inferior parietal lobule (BA7), left cingulate gyrus (BA32), left insula (BA13), and cerebellum. Activation regions in NMO patients included bilateral superior temporal gyri (BA22), left inferior frontal gyrus (BA9), right cingulate gyrus (BA32), right inferior parietal gyrus (BA40), left insula (BA13) and cerebellum. Some dispersed cognition related regions are greater in the patients. Conclusions The present study showed altered cerebral activation during mPASAT in patients with NMO relative to healthy controls. These results are speculated to provide further evidence for brain plasticity in patients with NMO.
KW - Brain plasticity
KW - Cognition
KW - fMRI
KW - Neuromyelitis optica
UR - http://www.scopus.com/inward/record.url?scp=85027884961&partnerID=8YFLogxK
U2 - 10.1016/j.ejrad.2017.08.012
DO - 10.1016/j.ejrad.2017.08.012
M3 - Article
C2 - 28987668
AN - SCOPUS:85027884961
VL - 95
SP - 197
EP - 201
JO - European Journal of Radiology
JF - European Journal of Radiology
SN - 0720-048X
ER -