Abnormal anatomical connectivity between the amygdala and orbitofrontal cortex in Conduct Disorder

Luca Passamonti, Graeme Fairchild, Alex Fornito, Ian M Goodyer, Ian Nimmo-Smith, Cindy C Hagan, Andrew J Calder

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)

Abstract

Previous research suggested that structural and functional abnormalities within the amygdala and orbitofrontal cortex contribute to the pathophysiology of Conduct Disorder (CD). Here, we investigated whether the integrity of the white-matter pathways connecting these regions is abnormal and thus may represent a putative neurobiological marker for CD.
Original languageEnglish
Article numbere48789
Number of pages9
JournalPLoS ONE
Volume7
Issue number11
DOIs
Publication statusPublished - 7 Nov 2012
Externally publishedYes

Keywords

  • ADHD
  • diffusion tensor imaging
  • adolescents
  • amygdala
  • eigenvalues
  • microstructure
  • central nervous system
  • tractography

Cite this