Abnormal anal cytology in high-risk human papilloma virus infection in HIV-infected Australians

J. S. Anderson, J. Hoy, R. Hillman, C. Gittleson, G. Hartel, G. Medley, R. Basser

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Objective: To assess the prevalence of abnormal anal cytology and high-risk human papilloma virus (HPV)-type infection in HIV-infected people with a CD4 cell count >300 cells/μl. Methods: The clinic-based patient population included 126 HIV-infected people: 124 men who have sex with men, and two women (median age 45 years; CD4 cell count >300 cells/μl). Anal cytology swabs were placed into liquid-based medium for HPV typing by Hybrid Capture-2 assay and cytological assessment, by a single cytopathologist. Results: 106 (84%) participants were infected with high-risk HPV; 17 (14%) had no high-risk types of HPV detected; three (2%) had no HPV assay result because of an inadequate sample. Sixteen (13%) participants had cytological evidence of high-grade squamous intraepithelial (HGSIL) changes, 100% of whom had high-risk HPV types detected, and 13 (10%) had atypical squamous cells of undetermined significance with possible high-grade changes (ASCUS-H), 92% of whom had high-risk HPV types detected. Low-grade changes (LSIL) were detected in 24 (19%) participants, 96% of whom had high-risk HPV types, 32 (25%) had ASCUS with 88% high-risk HPV types, 30 (24%) had normal cytology with 73% high-risk HPV types, and 11 (9%) samples were inadequate for cytological assessment. The odds ratio of participants with high-risk HPV having abnormal anal cytology on anal swab was 5.03 (95% CI 1.45 to 17.39). Discussion: High-risk HPV types are common in this HIV+ population with a CD4 cell count >300 cells/μl. The presence of high-risk HPV types was associated with abnormal anal cytology such as HGSIL and ASCUS-H.

Original languageEnglish
Pages (from-to)94-96
Number of pages3
JournalSexually Transmitted Infections
Volume84
Issue number2
DOIs
Publication statusPublished - 1 Apr 2008

Cite this

Anderson, J. S. ; Hoy, J. ; Hillman, R. ; Gittleson, C. ; Hartel, G. ; Medley, G. ; Basser, R. / Abnormal anal cytology in high-risk human papilloma virus infection in HIV-infected Australians. In: Sexually Transmitted Infections. 2008 ; Vol. 84, No. 2. pp. 94-96.
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abstract = "Objective: To assess the prevalence of abnormal anal cytology and high-risk human papilloma virus (HPV)-type infection in HIV-infected people with a CD4 cell count >300 cells/μl. Methods: The clinic-based patient population included 126 HIV-infected people: 124 men who have sex with men, and two women (median age 45 years; CD4 cell count >300 cells/μl). Anal cytology swabs were placed into liquid-based medium for HPV typing by Hybrid Capture-2 assay and cytological assessment, by a single cytopathologist. Results: 106 (84{\%}) participants were infected with high-risk HPV; 17 (14{\%}) had no high-risk types of HPV detected; three (2{\%}) had no HPV assay result because of an inadequate sample. Sixteen (13{\%}) participants had cytological evidence of high-grade squamous intraepithelial (HGSIL) changes, 100{\%} of whom had high-risk HPV types detected, and 13 (10{\%}) had atypical squamous cells of undetermined significance with possible high-grade changes (ASCUS-H), 92{\%} of whom had high-risk HPV types detected. Low-grade changes (LSIL) were detected in 24 (19{\%}) participants, 96{\%} of whom had high-risk HPV types, 32 (25{\%}) had ASCUS with 88{\%} high-risk HPV types, 30 (24{\%}) had normal cytology with 73{\%} high-risk HPV types, and 11 (9{\%}) samples were inadequate for cytological assessment. The odds ratio of participants with high-risk HPV having abnormal anal cytology on anal swab was 5.03 (95{\%} CI 1.45 to 17.39). Discussion: High-risk HPV types are common in this HIV+ population with a CD4 cell count >300 cells/μl. The presence of high-risk HPV types was associated with abnormal anal cytology such as HGSIL and ASCUS-H.",
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Abnormal anal cytology in high-risk human papilloma virus infection in HIV-infected Australians. / Anderson, J. S.; Hoy, J.; Hillman, R.; Gittleson, C.; Hartel, G.; Medley, G.; Basser, R.

In: Sexually Transmitted Infections, Vol. 84, No. 2, 01.04.2008, p. 94-96.

Research output: Contribution to journalArticleResearchpeer-review

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