ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts

Hidayati Mohd Sha'Ari; Batoul Sadat Haerian; Larry Baum; Junji Saruwatari; Hui Jan Tan; Mohd Hanip Rafia; Azman Ali Raymond; Patrick Kwan; Takateru Ishitsu; Kazuko Nakagawa; Kheng Seang Lim; Zahurin Mohamed

doi:10.2217/pgs.13.239

ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts

Hidayati Mohd Sha'Ari, Batoul Sadat Haerian, Larry Baum, Junji Saruwatari, Hui Jan Tan, Mohd Hanip Rafia, Azman Ali Raymond, Patrick Kwan, Takateru Ishitsu, Kazuko Nakagawa, Kheng Seang Lim, Zahurin Mohamed

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

Aim: To examine the relevance of ABCC2 polymorphisms to drug responsiveness in epilepsy cohorts from the Asia Pacific region. Materials & methods: The rs2273697 and rs3740066 polymorphisms were genotyped in 2056 Malaysian (55%), Hong Kong (32%) and Japanese (13%) epilepsy patients. Results: Significant allele association of rs2273697 was observed in Chinese females with epilepsy, Malaysian Chinese patients with generalized seizure and Japanese patients with partial seizure for the AA versus GG genotype model and Malaysian Chinese patients with generalized seizure for the GA versus GG and autosomal dominant models. Significant association of the rs3740066 allele was observed in Malaysian females of Malay origin with cryptogenic epilepsy and Chinese patients with partial seizure and for genotypes in Malay patients with cryptogenic epilepsy for the CT versus CC and autosomal dominant genotype models. Significant results were observed for all haplotypes, but following Bonferroni correction, only the GT haplotype in Chinese patients remained significant. Conclusion: This study suggests that the GT haplotype might be a risk factor for resistance to medication in Chinese patients.

Original language	English
Pages (from-to)	459-466
Number of pages	8
Journal	Pharmacogenomics
Volume	15
Issue number	4
DOIs	https://doi.org/10.2217/pgs.13.239
Publication status	Published - 1 Jan 2014
Externally published	Yes

Keywords

drug responsiveness
epilepsy
polymorphism

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title = "ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts",

abstract = "Aim: To examine the relevance of ABCC2 polymorphisms to drug responsiveness in epilepsy cohorts from the Asia Pacific region. Materials & methods: The rs2273697 and rs3740066 polymorphisms were genotyped in 2056 Malaysian (55%), Hong Kong (32%) and Japanese (13%) epilepsy patients. Results: Significant allele association of rs2273697 was observed in Chinese females with epilepsy, Malaysian Chinese patients with generalized seizure and Japanese patients with partial seizure for the AA versus GG genotype model and Malaysian Chinese patients with generalized seizure for the GA versus GG and autosomal dominant models. Significant association of the rs3740066 allele was observed in Malaysian females of Malay origin with cryptogenic epilepsy and Chinese patients with partial seizure and for genotypes in Malay patients with cryptogenic epilepsy for the CT versus CC and autosomal dominant genotype models. Significant results were observed for all haplotypes, but following Bonferroni correction, only the GT haplotype in Chinese patients remained significant. Conclusion: This study suggests that the GT haplotype might be a risk factor for resistance to medication in Chinese patients.",

keywords = "drug responsiveness, epilepsy, polymorphism",

author = "Sha'Ari, {Hidayati Mohd} and Haerian, {Batoul Sadat} and Larry Baum and Junji Saruwatari and Tan, {Hui Jan} and Rafia, {Mohd Hanip} and Raymond, {Azman Ali} and Patrick Kwan and Takateru Ishitsu and Kazuko Nakagawa and Lim, {Kheng Seang} and Zahurin Mohamed",

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doi = "10.2217/pgs.13.239",

language = "English",

volume = "15",

pages = "459--466",

journal = "Pharmacogenomics",

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TY - JOUR

T1 - ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts

AU - Sha'Ari, Hidayati Mohd

AU - Haerian, Batoul Sadat

AU - Baum, Larry

AU - Saruwatari, Junji

AU - Tan, Hui Jan

AU - Rafia, Mohd Hanip

AU - Raymond, Azman Ali

AU - Kwan, Patrick

AU - Ishitsu, Takateru

AU - Nakagawa, Kazuko

AU - Lim, Kheng Seang

AU - Mohamed, Zahurin

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Aim: To examine the relevance of ABCC2 polymorphisms to drug responsiveness in epilepsy cohorts from the Asia Pacific region. Materials & methods: The rs2273697 and rs3740066 polymorphisms were genotyped in 2056 Malaysian (55%), Hong Kong (32%) and Japanese (13%) epilepsy patients. Results: Significant allele association of rs2273697 was observed in Chinese females with epilepsy, Malaysian Chinese patients with generalized seizure and Japanese patients with partial seizure for the AA versus GG genotype model and Malaysian Chinese patients with generalized seizure for the GA versus GG and autosomal dominant models. Significant association of the rs3740066 allele was observed in Malaysian females of Malay origin with cryptogenic epilepsy and Chinese patients with partial seizure and for genotypes in Malay patients with cryptogenic epilepsy for the CT versus CC and autosomal dominant genotype models. Significant results were observed for all haplotypes, but following Bonferroni correction, only the GT haplotype in Chinese patients remained significant. Conclusion: This study suggests that the GT haplotype might be a risk factor for resistance to medication in Chinese patients.

AB - Aim: To examine the relevance of ABCC2 polymorphisms to drug responsiveness in epilepsy cohorts from the Asia Pacific region. Materials & methods: The rs2273697 and rs3740066 polymorphisms were genotyped in 2056 Malaysian (55%), Hong Kong (32%) and Japanese (13%) epilepsy patients. Results: Significant allele association of rs2273697 was observed in Chinese females with epilepsy, Malaysian Chinese patients with generalized seizure and Japanese patients with partial seizure for the AA versus GG genotype model and Malaysian Chinese patients with generalized seizure for the GA versus GG and autosomal dominant models. Significant association of the rs3740066 allele was observed in Malaysian females of Malay origin with cryptogenic epilepsy and Chinese patients with partial seizure and for genotypes in Malay patients with cryptogenic epilepsy for the CT versus CC and autosomal dominant genotype models. Significant results were observed for all haplotypes, but following Bonferroni correction, only the GT haplotype in Chinese patients remained significant. Conclusion: This study suggests that the GT haplotype might be a risk factor for resistance to medication in Chinese patients.

KW - drug responsiveness

KW - epilepsy

KW - polymorphism

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DO - 10.2217/pgs.13.239

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AN - SCOPUS:84896365015

SN - 1462-2416

VL - 15

SP - 459

EP - 466

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 4

ER -

ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts

Abstract

Keywords

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