ABC Transporters: The Breast Cancer Resistance Protein

Liam Koehn

doi:10.1007/978-3-030-51519-5_80-1

ABC Transporters: The Breast Cancer Resistance Protein

Research output: Chapter in Book/Report/Conference proceeding › Encyclopaedia / Dictionary Entry › Other › peer-review

Abstract

Breast cancer resistance protein (BCRP) is a member of the adenosine triphosphate-binding cassette (ABC) efflux transporter family. Two BCRP proteins dimerize to form a membrane-bound transport system. When positioned in the external membrane of a cell, BCRP can limit the transfer of substrate molecules into cells or across cellular interfaces. BCRP is located at cellular interfaces involved in the processes of absorption, distribution, metabolism, and excretion (ADME), where it can influence the pharmacokinetics of many medications and their metabolites.

Original language	English
Title of host publication	The ADME Encyclopedia
Subtitle of host publication	A Comprehensive Guide on Biopharmacy and Pharmacokinetics
Editors	Alan Talevi
Place of Publication	Cham Switzerland
Publisher	Springer
Pages	1-8
Number of pages	8
ISBN (Print)	978-3-030-51519-5
DOIs	https://doi.org/10.1007/978-3-030-51519-5_80-1
Publication status	Published - 2021
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-030-51519-5_80-1

Cite this

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abstract = "Breast cancer resistance protein (BCRP) is a member of the adenosine triphosphate-binding cassette (ABC) efflux transporter family. Two BCRP proteins dimerize to form a membrane-bound transport system. When positioned in the external membrane of a cell, BCRP can limit the transfer of substrate molecules into cells or across cellular interfaces. BCRP is located at cellular interfaces involved in the processes of absorption, distribution, metabolism, and excretion (ADME), where it can influence the pharmacokinetics of many medications and their metabolites.",

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AB - Breast cancer resistance protein (BCRP) is a member of the adenosine triphosphate-binding cassette (ABC) efflux transporter family. Two BCRP proteins dimerize to form a membrane-bound transport system. When positioned in the external membrane of a cell, BCRP can limit the transfer of substrate molecules into cells or across cellular interfaces. BCRP is located at cellular interfaces involved in the processes of absorption, distribution, metabolism, and excretion (ADME), where it can influence the pharmacokinetics of many medications and their metabolites.

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