ABC Transporters: Multidrug Resistance-Associated Proteins

Liam Koehn

doi:10.1007/978-3-030-51519-5_79-1

ABC Transporters: Multidrug Resistance-Associated Proteins

Liam Koehn

Research output: Chapter in Book/Report/Conference proceeding › Encyclopaedia / Dictionary Entry › Other › peer-review

Abstract

The multidrug resistance-associated proteins (MRPs) are a family of transporters that can move a variety of molecular substrates across membranes. MRPs contribute to a host of endogenous cellular mechanisms, including the transfer of molecules between subcellular compartments and the removal of metabolites and toxic by-products from cells toward areas of excretion. MRP transporters can also bind and export many xenobiotics, often in their metabolite forms. This allows members of the MRP transporter family to influence the absorption, distribution, metabolism, and excretion (ADME) of certain medications.

Original language	English
Title of host publication	The ADME Encyclopedia
Subtitle of host publication	A Comprehensive Guide on Biopharmacy and Pharmacokinetics
Editors	Alan Talevi
Place of Publication	Cham Switzerland
Publisher	Springer
Pages	1-8
Number of pages	8
ISBN (Print)	978-3-030-51519-5
DOIs	https://doi.org/10.1007/978-3-030-51519-5_79-1
Publication status	Published - 2021
Externally published	Yes

Access to Document

10.1007/978-3-030-51519-5_79-1

Cite this

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title = "ABC Transporters: Multidrug Resistance-Associated Proteins",

abstract = "The multidrug resistance-associated proteins (MRPs) are a family of transporters that can move a variety of molecular substrates across membranes. MRPs contribute to a host of endogenous cellular mechanisms, including the transfer of molecules between subcellular compartments and the removal of metabolites and toxic by-products from cells toward areas of excretion. MRP transporters can also bind and export many xenobiotics, often in their metabolite forms. This allows members of the MRP transporter family to influence the absorption, distribution, metabolism, and excretion (ADME) of certain medications.",

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AB - The multidrug resistance-associated proteins (MRPs) are a family of transporters that can move a variety of molecular substrates across membranes. MRPs contribute to a host of endogenous cellular mechanisms, including the transfer of molecules between subcellular compartments and the removal of metabolites and toxic by-products from cells toward areas of excretion. MRP transporters can also bind and export many xenobiotics, often in their metabolite forms. This allows members of the MRP transporter family to influence the absorption, distribution, metabolism, and excretion (ADME) of certain medications.

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