ABC Transporters: Drug Transfer Across Cellular Interfaces

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Abstract

Cellular interfaces are groups of adjacent cells that separate two compartments of the human body. For a drug to get from one side of a cellular interface to the other, it needs to find a passage across this physical separation point. Adenosine triphosphate-binding cassette (ABC) efflux transporters are a family of membrane-bound export pumps that are positioned on the external membrane of cells, such as those that form cellular interfaces. As substrate molecules attempt to cross an interface, ABC transporters can efflux these molecules back to their original compartment, thereby limiting transfer. The likelihood that an ABC efflux transporter will intercept a molecule will depend on the biochemical properties of that molecule and its ability to access alternate routes of passage across a particular interface.
Original languageEnglish
Title of host publicationThe ADME Encyclopedia
Subtitle of host publicationA Comprehensive Guide on Biopharmacy and Pharmacokinetics
EditorsAlan Talevi
Place of PublicationCham Switzerland
PublisherSpringer
Pages1-8
Number of pages8
ISBN (Print)978-3-030-51519-5
DOIs
Publication statusPublished - 2021
Externally publishedYes

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