ABC Transporters: An Overview

Liam Koehn

doi:10.1007/978-3-030-51519-5_76-1

ABC Transporters: An Overview

Research output: Chapter in Book/Report/Conference proceeding › Encyclopaedia / Dictionary Entry › Other › peer-review

Abstract

A superfamily of proteins that primarily position within membranes and utilize energy in the form of adenosine triphosphate (ATP) to move substrates across that lipid bilayer. In humans, this transport typically involves the efflux of molecules from a cell to the extracellular fluid. This can support homeostatic cellular functioning by removing certain molecules and metabolites from a cell. It can also limit the access of drugs to active sites located within a cell or restrict the transport of drugs across cellular interfaces.

Original language	English
Title of host publication	The ADME Encyclopedia
Subtitle of host publication	A Comprehensive Guide on Biopharmacy and Pharmacokinetics
Editors	Alan Talevi
Place of Publication	Cham Switzerland
Publisher	Springer
Pages	1-10
Number of pages	10
ISBN (Print)	978-3-030-51519-5
DOIs	https://doi.org/10.1007/978-3-030-51519-5_76-1
Publication status	Published - 2021
Externally published	Yes

Access to Document

10.1007/978-3-030-51519-5_76-1

Cite this

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title = "ABC Transporters: An Overview",

abstract = "A superfamily of proteins that primarily position within membranes and utilize energy in the form of adenosine triphosphate (ATP) to move substrates across that lipid bilayer. In humans, this transport typically involves the efflux of molecules from a cell to the extracellular fluid. This can support homeostatic cellular functioning by removing certain molecules and metabolites from a cell. It can also limit the access of drugs to active sites located within a cell or restrict the transport of drugs across cellular interfaces.",

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AB - A superfamily of proteins that primarily position within membranes and utilize energy in the form of adenosine triphosphate (ATP) to move substrates across that lipid bilayer. In humans, this transport typically involves the efflux of molecules from a cell to the extracellular fluid. This can support homeostatic cellular functioning by removing certain molecules and metabolites from a cell. It can also limit the access of drugs to active sites located within a cell or restrict the transport of drugs across cellular interfaces.

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