ABC Transporters: An Overview

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Abstract

A superfamily of proteins that primarily position within membranes and utilize energy in the form of adenosine triphosphate (ATP) to move substrates across that lipid bilayer. In humans, this transport typically involves the efflux of molecules from a cell to the extracellular fluid. This can support homeostatic cellular functioning by removing certain molecules and metabolites from a cell. It can also limit the access of drugs to active sites located within a cell or restrict the transport of drugs across cellular interfaces.
Original languageEnglish
Title of host publicationThe ADME Encyclopedia
Subtitle of host publicationA Comprehensive Guide on Biopharmacy and Pharmacokinetics
EditorsAlan Talevi
Place of PublicationCham Switzerland
PublisherSpringer
Pages1-10
Number of pages10
ISBN (Print)978-3-030-51519-5
DOIs
Publication statusPublished - 2021
Externally publishedYes

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