Abacavir exposure and cardiovascular risk factors in HIV-positive patients with coronary heart disease: a retrospective case-control study

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Abstract

We performed a retrospective case-control study of HIV-positive patients seen from January 1996 to December 2009 to evaluate the impact of HIV suppression and exposure to specific ARVs on the incidence of CHD. Results: Cases (n = 68) were HIV-positive with evidence of CHD. Two age- and sex-matched HIV-positive controls (n = 136) without a diagnosis of CHD were assigned for each case. The cumulative incidence of CHD in the period covered by the study was 3.8 , with an incidence of 8.5 cases per 1000 patient-years of follow up. Cases had an increased likelihood of having hypertension (odds ratio (OR): 6.62, P <0.001), a family history of CHD (OR: 5.82, P <0.001), lower high-density lipoprotein levels (OR: 0.28, P = 0.025) and higher Framingham risk scores compared with controls. Following adjustment for traditional cardiovascular risk factors, the presence of CHD was significantly associated with the current use of abacavir (OR: 2.10, P = 0.03). Protease inhibitor therapy, HIV viral load and duration of known HIV infection were not predictive of CHD in our patient population. Our data add to the evidence that abacavir use is associated with CHD in HIV-positive patients in Australia.
Original languageEnglish
Pages (from-to)97 - 101
Number of pages5
JournalSexual Health
Volume10
Issue number2
DOIs
Publication statusPublished - 2013

Cite this

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title = "Abacavir exposure and cardiovascular risk factors in HIV-positive patients with coronary heart disease: a retrospective case-control study",
abstract = "We performed a retrospective case-control study of HIV-positive patients seen from January 1996 to December 2009 to evaluate the impact of HIV suppression and exposure to specific ARVs on the incidence of CHD. Results: Cases (n = 68) were HIV-positive with evidence of CHD. Two age- and sex-matched HIV-positive controls (n = 136) without a diagnosis of CHD were assigned for each case. The cumulative incidence of CHD in the period covered by the study was 3.8 , with an incidence of 8.5 cases per 1000 patient-years of follow up. Cases had an increased likelihood of having hypertension (odds ratio (OR): 6.62, P <0.001), a family history of CHD (OR: 5.82, P <0.001), lower high-density lipoprotein levels (OR: 0.28, P = 0.025) and higher Framingham risk scores compared with controls. Following adjustment for traditional cardiovascular risk factors, the presence of CHD was significantly associated with the current use of abacavir (OR: 2.10, P = 0.03). Protease inhibitor therapy, HIV viral load and duration of known HIV infection were not predictive of CHD in our patient population. Our data add to the evidence that abacavir use is associated with CHD in HIV-positive patients in Australia.",
author = "Trevillyan, {Janine Maree} and Cheng, {Allen Cheuk-Seng} and Hoy, {Jennifer F}",
year = "2013",
doi = "10.1071/SH12081",
language = "English",
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pages = "97 -- 101",
journal = "Sexual Health",
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T1 - Abacavir exposure and cardiovascular risk factors in HIV-positive patients with coronary heart disease: a retrospective case-control study

AU - Trevillyan, Janine Maree

AU - Cheng, Allen Cheuk-Seng

AU - Hoy, Jennifer F

PY - 2013

Y1 - 2013

N2 - We performed a retrospective case-control study of HIV-positive patients seen from January 1996 to December 2009 to evaluate the impact of HIV suppression and exposure to specific ARVs on the incidence of CHD. Results: Cases (n = 68) were HIV-positive with evidence of CHD. Two age- and sex-matched HIV-positive controls (n = 136) without a diagnosis of CHD were assigned for each case. The cumulative incidence of CHD in the period covered by the study was 3.8 , with an incidence of 8.5 cases per 1000 patient-years of follow up. Cases had an increased likelihood of having hypertension (odds ratio (OR): 6.62, P <0.001), a family history of CHD (OR: 5.82, P <0.001), lower high-density lipoprotein levels (OR: 0.28, P = 0.025) and higher Framingham risk scores compared with controls. Following adjustment for traditional cardiovascular risk factors, the presence of CHD was significantly associated with the current use of abacavir (OR: 2.10, P = 0.03). Protease inhibitor therapy, HIV viral load and duration of known HIV infection were not predictive of CHD in our patient population. Our data add to the evidence that abacavir use is associated with CHD in HIV-positive patients in Australia.

AB - We performed a retrospective case-control study of HIV-positive patients seen from January 1996 to December 2009 to evaluate the impact of HIV suppression and exposure to specific ARVs on the incidence of CHD. Results: Cases (n = 68) were HIV-positive with evidence of CHD. Two age- and sex-matched HIV-positive controls (n = 136) without a diagnosis of CHD were assigned for each case. The cumulative incidence of CHD in the period covered by the study was 3.8 , with an incidence of 8.5 cases per 1000 patient-years of follow up. Cases had an increased likelihood of having hypertension (odds ratio (OR): 6.62, P <0.001), a family history of CHD (OR: 5.82, P <0.001), lower high-density lipoprotein levels (OR: 0.28, P = 0.025) and higher Framingham risk scores compared with controls. Following adjustment for traditional cardiovascular risk factors, the presence of CHD was significantly associated with the current use of abacavir (OR: 2.10, P = 0.03). Protease inhibitor therapy, HIV viral load and duration of known HIV infection were not predictive of CHD in our patient population. Our data add to the evidence that abacavir use is associated with CHD in HIV-positive patients in Australia.

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U2 - 10.1071/SH12081

DO - 10.1071/SH12081

M3 - Article

VL - 10

SP - 97

EP - 101

JO - Sexual Health

JF - Sexual Health

SN - 1448-5028

IS - 2

ER -