A1 adenosine receptor agonists: Medicinal chemistry and therapeutic potential

S. A. Hutchinson, Peter J. Scammells

Research output: Contribution to journalReview ArticleResearchpeer-review

35 Citations (Scopus)


Adenosine receptors are widely distributed in the body and modulate numerous physiological processes. Four receptor subtypes (termed A1, A2A, A2B and A3) have been identified based on their pharmacological profile and cloning. Activation of the A1 adenosine receptors produces a number of effects including a reduction in heart rate and atrial contractility, the attenuation of the stimulatory actions of catecholamines on the heart as well as a reduction of lipolysis in adipose tissue. As a result, A'1AR agonists have been targeted as anti-arrhythmic and cardioprotective agents. This review discusses the synthesis, structure-activity relationships and therapeutic potential of A1AR agonists. © 2004 Bentham Science Publishers Ltd.
Original languageEnglish
Pages (from-to)2021-2039
Number of pages19
JournalCurrent Pharmaceutical Design
Issue number17
Publication statusPublished - 12 Jul 2004

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