TY - JOUR
T1 - A worldwide survey of human male demographic history based on Y-SNP and Y-STR data from the HGDP-CEPH populations
AU - Shi, Wentao
AU - Ayub, Qasim
AU - Vermeulen, Mark
AU - Shao, Rong Guang
AU - Zuniga, Sofia
AU - Van Der Gaag, Kristiaan
AU - De Knijff, Peter
AU - Kayser, Manfred
AU - Xue, Yali
AU - Tyler-Smith, Chris
PY - 2010/2
Y1 - 2010/2
N2 - We have investigated human male demographic history using 590 males from 51 populations in the Human Genome Diversity Project-Centre d'Étude du Polymorphisme Humain worldwide panel, typed with 37 Y-chromosomal Single Nucleotide Polymorphisms and 65 Y-chromosomal Short Tandem Repeats and analyzed with the program Bayesian Analysis of Trees With Internal Node Generation. The general patterns we observe show a gradient from the oldest population time to the most recent common ancestors (TMRCAs) and expansion times together with the largest effective population sizes in Africa, to the youngest times and smallest effective population sizes in the Americas. These parameters are significantly negatively correlated with distance from East Africa, and the patterns are consistent with most other studies of human variation and history. In contrast, growth rate showed a weaker correlation in the opposite direction. Y-lineage diversity and TMRCA also decrease with distance from East Africa, supporting a model of expansion with serial founder events starting from this source. A number of individual populations diverge from these general patterns, including previously documented examples such as recent expansions of the Yoruba in Africa, Basques in Europe, and Yakut in Northern Asia. However, some unexpected demographic histories were also found, including low growth rates in the Hazara and Kalash from Pakistan and recent expansion of the Mozabites in North Africa.
AB - We have investigated human male demographic history using 590 males from 51 populations in the Human Genome Diversity Project-Centre d'Étude du Polymorphisme Humain worldwide panel, typed with 37 Y-chromosomal Single Nucleotide Polymorphisms and 65 Y-chromosomal Short Tandem Repeats and analyzed with the program Bayesian Analysis of Trees With Internal Node Generation. The general patterns we observe show a gradient from the oldest population time to the most recent common ancestors (TMRCAs) and expansion times together with the largest effective population sizes in Africa, to the youngest times and smallest effective population sizes in the Americas. These parameters are significantly negatively correlated with distance from East Africa, and the patterns are consistent with most other studies of human variation and history. In contrast, growth rate showed a weaker correlation in the opposite direction. Y-lineage diversity and TMRCA also decrease with distance from East Africa, supporting a model of expansion with serial founder events starting from this source. A number of individual populations diverge from these general patterns, including previously documented examples such as recent expansions of the Yoruba in Africa, Basques in Europe, and Yakut in Northern Asia. However, some unexpected demographic histories were also found, including low growth rates in the Hazara and Kalash from Pakistan and recent expansion of the Mozabites in North Africa.
KW - BATWING
KW - HGDP-CEPH
KW - Male demographic history
KW - Serial founder model
KW - Y-SNP
KW - Y-STR
UR - http://www.scopus.com/inward/record.url?scp=74549133571&partnerID=8YFLogxK
U2 - 10.1093/molbev/msp243
DO - 10.1093/molbev/msp243
M3 - Article
C2 - 19822636
AN - SCOPUS:74549133571
SN - 0737-4038
VL - 27
SP - 385
EP - 393
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
IS - 2
ER -