TY - JOUR
T1 - A wolbachia symbiont in aedes aegypti limits infection with dengue, chikungunya, and plasmodium
AU - Moreira, Luciano
AU - Iturbe-Ormaetxe, Inaki
AU - Jeffery, Jason
AU - Lu, Guangjin
AU - Pyke, Alyssa
AU - Hedges, Lauren
AU - Rocha, Bruno
AU - Hall-Mendelin, Sonja
AU - Day, Andrew
AU - Riegler, Markus
AU - Hugo, Leon
AU - Johnson, Karyn
AU - Kay, Brian
AU - McGraw, Elizabeth
AU - van den Hurk, Andrew F
AU - Rayn, Peter
AU - O'Neill, Scott Leslie
PY - 2009
Y1 - 2009
N2 - Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60 of all insect species. While Wolbachia is commonly found in many mosquitoes it is absent from the species that are considered to be of major importance for the transmission of human pathogens. The successful introduction of a life-shortening strain of Wolbachia into the dengue vector Aedes aegypti that halves adult lifespan has recently been reported. Here we show that this same Wolbachia infection also directly inhibits the ability of a range of pathogens to infect this mosquito species. The effect is Wolbachia strain specific and relates to Wolbachia priming of the mosquito innate immune system and potentially competition for limiting cellular resources required for pathogen replication. We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases.
AB - Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60 of all insect species. While Wolbachia is commonly found in many mosquitoes it is absent from the species that are considered to be of major importance for the transmission of human pathogens. The successful introduction of a life-shortening strain of Wolbachia into the dengue vector Aedes aegypti that halves adult lifespan has recently been reported. Here we show that this same Wolbachia infection also directly inhibits the ability of a range of pathogens to infect this mosquito species. The effect is Wolbachia strain specific and relates to Wolbachia priming of the mosquito innate immune system and potentially competition for limiting cellular resources required for pathogen replication. We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases.
UR - http://www.sciencedirect.com/science/article/pii/S0092867409015001
U2 - 10.1016/j.cell.2009.11.042
DO - 10.1016/j.cell.2009.11.042
M3 - Article
SN - 0092-8674
VL - 139
SP - 1268
EP - 1278
JO - Cell
JF - Cell
IS - 7
ER -
