A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases

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223 Citations (Scopus)

Abstract

Catch Fe if you can. Many siderophores are peptides biosynthesised by the well-studied nonribosomal peptide synthetase (NRPS) multienzyme family. However, recent research has demonstrated that several siderophores, for example desferrioxamine E, are assembled via an NRPS-independent siderophore (NIS) pathway. In this minireview, research progress to date on the NIS pathway is summarised, and the distribution and mechanistic rationalisations of the pathway are analysed.

Original languageEnglish
Pages (from-to)601-611
Number of pages11
JournalChemBioChem
Volume6
Issue number4
DOIs
Publication statusPublished - 1 Apr 2005
Externally publishedYes

Keywords

  • Biosynthesis
  • Enzymes
  • Genomics
  • Natural products
  • Siderophores

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