A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc

Gojko Buncic; Paul S. Donnelly; Brett M. Paterson; Jonathan M. White; Matthias Zimmermann; Zhiguang Xiao; Anthony G. Wedd

doi:10.1021/ic902370a

A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc

Gojko Buncic, Paul S. Donnelly, Brett M. Paterson, Jonathan M. White, Matthias Zimmermann, Zhiguang Xiao, Anthony G. Wedd

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

The first member of a water-soluble family of bis(thiosemicarbazone) ligands is reported. It forms a 1:1 complex with Zn" that absorbs intensely in the visible region (λ_max= 414 nm; ε= 1.8(4) x 104M^-1 cm^-1; pH 7.3). Its affinity for Zn^II (KD = 5.9(3) x 10^-9 M at pH 7.3) was determined by competition with ligand ethylene glycol O,O-bis(2-aminoethyl)-N,N,N,N-tetraacetic acid. Its potential application as a chromophoric probe was demonstrated by estimation of the Zn^II binding affinities of the soluble metal-binding domains of two plant metal-transporting proteins.

Original language	English
Pages (from-to)	3071-3073
Number of pages	3
Journal	Inorganic Chemistry
Volume	49
Issue number	7
DOIs	https://doi.org/10.1021/ic902370a
Publication status	Published - 5 Apr 2010
Externally published	Yes

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title = "A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc",

abstract = "The first member of a water-soluble family of bis(thiosemicarbazone) ligands is reported. It forms a 1:1 complex with Zn{"} that absorbs intensely in the visible region (λmax= 414 nm; ε= 1.8(4) x 104M-1 cm-1; pH 7.3). Its affinity for ZnII (KD = 5.9(3) x 10-9 M at pH 7.3) was determined by competition with ligand ethylene glycol O,O-bis(2-aminoethyl)-N,N,N,N-tetraacetic acid. Its potential application as a chromophoric probe was demonstrated by estimation of the ZnII binding affinities of the soluble metal-binding domains of two plant metal-transporting proteins.",

author = "Gojko Buncic and Donnelly, {Paul S.} and Paterson, {Brett M.} and White, {Jonathan M.} and Matthias Zimmermann and Zhiguang Xiao and Wedd, {Anthony G.}",

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A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc. / Buncic, Gojko; Donnelly, Paul S.; Paterson, Brett M.; White, Jonathan M.; Zimmermann, Matthias; Xiao, Zhiguang; Wedd, Anthony G.

In: Inorganic Chemistry, Vol. 49, No. 7, 05.04.2010, p. 3071-3073.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc

AU - Buncic, Gojko

AU - Donnelly, Paul S.

AU - Paterson, Brett M.

AU - White, Jonathan M.

AU - Zimmermann, Matthias

AU - Xiao, Zhiguang

AU - Wedd, Anthony G.

PY - 2010/4/5

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AB - The first member of a water-soluble family of bis(thiosemicarbazone) ligands is reported. It forms a 1:1 complex with Zn" that absorbs intensely in the visible region (λmax= 414 nm; ε= 1.8(4) x 104M-1 cm-1; pH 7.3). Its affinity for ZnII (KD = 5.9(3) x 10-9 M at pH 7.3) was determined by competition with ligand ethylene glycol O,O-bis(2-aminoethyl)-N,N,N,N-tetraacetic acid. Its potential application as a chromophoric probe was demonstrated by estimation of the ZnII binding affinities of the soluble metal-binding domains of two plant metal-transporting proteins.

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JO - Inorganic Chemistry

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SN - 0020-1669

IS - 7

ER -

A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc

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