A versatile monoclonal antibody specific to human SERPINB5

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Abstract

Maspin (SERPINB5) is a member of the Clade B subgroup of the large superfamily of serine protease inhibitors. It is proposed that maspin is a tumor suppressor; however, its molecular role remains to be elucidated. Here we report the characterization of a mouse monoclonal antibody directed against human maspin. This antibody, 16F7, recognizes maspin in both its native and denatured form, unlike several other commercial antibodies tested in this study. It will be a useful and versatile tool for future analyses of the biological function of maspin.
Original languageEnglish
Pages (from-to)333 - 339
Number of pages7
JournalHybridoma
Volume31
Issue number5
DOIs
Publication statusPublished - 2012

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