A vasoactive role for endogenous relaxin in mesenteric arteries of male mice

Chen H Leo, Maria Jelinic, Jonathan H Gooi, Marianne Tare, Laura J Parry

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23 Citations (Scopus)

Abstract

The peptide hormone relaxin has striking effects on the vascular system. Specifically, endogenous relaxin treatment reduces myogenic reactivity through nitric oxide (NO)-mediated vasorelaxation and increases arterial compliance in small resistance arteries. However, less is known about the vascular roles of endogenous relaxin, particularly in males. Therefore, we used male wild-type (Rln+/+) and relaxin knockout (Rln-/-) mice to test the hypothesis that passive wall properties and vascular reactivity in mesenteric arteries would be compromised in Rln-/- mice. Passive compliance was determined in arteries (n = 8-9) mounted on a pressure myograph and in Ca2+-free Krebs containing 2 mM EGTA. Passive volume compliance was significantly (P = 0.01) decreased in the mesenteric arteries of Rln-/- mice. Vascular reactivity was assessed using wire myography. In mesenteric arteries (n = 5) of Rln-/- mice, there was a significant (P
Original languageEnglish
Article numbere107382
Number of pages12
JournalPLoS ONE
Volume9
Issue number9
DOIs
Publication statusPublished - 2014

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