A transdiagnostic perspective of constructs underlying obsessive-compulsive and related disorders: An international Delphi consensus study

Leonardo F Fontenelle, Erin Oldenhof, Maria Eduarda Moreira-de-Oliveira, Jonathan S. Abramowitz, Martin M. Antony, Danielle C. Cath, Adrian Carter, Darin Dougherty, Ygor A. Ferrão, Martijn Figee, Ben J. Harrison, Marcelo Hoexter, Jun Soo Kwon, Anne Küelz, Luísa Lazaro, Christine Lochner, Donatella Marazziti, David Mataix-Cols, Dean McKay, Euripedes C. MiguelSharon Morein-Zamir, Steffen Moritz, Gerald Nestadt, Kieron P O’Connor, Stefano Pallanti, Christine Purdon, Scott Rauch, Peggy Richter, Jean Yves Rotge, Roseli G. Shavitt, Carles Soriano-Mas, Vladan Starcevic, Dan J. Stein, Gail Steketee, Eric A. Storch, Steven Taylor, Odile A. van den Heuvel, David Veale, Douglas W. Woods, Antonio Verdejo-Garcia, Murat Yücel, The International OCRDs Neuroscience Consensus Group

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: The Research Domain Criteria seeks to bridge knowledge from neuroscience with clinical practice by promoting research into valid neurocognitive phenotypes and dimensions, irrespective of symptoms and diagnoses as currently conceptualized. While the Research Domain Criteria offers a vision of future research and practice, its 39 functional constructs need refinement to better target new phenotyping efforts. This study aimed to determine which Research Domain Criteria constructs are most relevant to understanding obsessive-compulsive and related disorders, based on a consensus between experts in the field of obsessive-compulsive and related disorders. Methods: Based on a modified Delphi method, 46 experts were recruited from Australia, Africa, Asia, Europe and the Americas. Over three rounds, experts had the opportunity to review their opinion in light of feedback from the previous round, which included how their response compared to other experts and a summary of comments given. Results: Thirty-four experts completed round one, of whom 28 (82%) completed round two and 24 (71%) completed round three. At the final round, four constructs were endorsed by ⩾75% of experts as ‘primary constructs’ and therefore central to understanding obsessive-compulsive and related disorders. Of these constructs, one came from the Positive Valence System (Habit), two from the Cognitive Control System (Response Selection/Inhibition and Performance Monitoring) and the final construct was an additional item suggested by experts (Compulsivity). Conclusion: This study identified four Research Domain Criteria constructs that, according to experts, cut across different obsessive-compulsive and related disorders. These constructs represent key areas for future investigation, and may have potential implications for clinical practice in terms of diagnostic processes and therapeutic management of obsessive-compulsive and related disorders.

Original languageEnglish
Pages (from-to)719-731
Number of pages13
JournalAustralian & New Zealand Journal of Psychiatry
Volume54
Issue number7
DOIs
Publication statusPublished - 1 Jul 2020

Keywords

  • cognitive control
  • compulsivity
  • habit
  • Obsessive-compulsive and related disorders
  • Research Domain Criteria

Cite this

Fontenelle, L. F., Oldenhof, E., Eduarda Moreira-de-Oliveira, M., Abramowitz, J. S., Antony, M. M., Cath, D. C., Carter, A., Dougherty, D., Ferrão, Y. A., Figee, M., Harrison, B. J., Hoexter, M., Soo Kwon, J., Küelz, A., Lazaro, L., Lochner, C., Marazziti, D., Mataix-Cols, D., McKay, D., ... The International OCRDs Neuroscience Consensus Group (2020). A transdiagnostic perspective of constructs underlying obsessive-compulsive and related disorders: An international Delphi consensus study. Australian & New Zealand Journal of Psychiatry, 54(7), 719-731. https://doi.org/10.1177/0004867420912327