Specificity counts: A template-based approach to protease inhibitors is presented using a core macrocycle that presents a generic ?-strand template for binding to protease active sites. This is then specifically functionalized at P2, and the C and N termini to give inhibitors of calpain 2, 20S proteasome, and HIV-1 protease.
|Pages (from-to)||1918 - 1921|
|Number of pages||4|
|Publication status||Published - 2013|