TY - JOUR
T1 - A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
AU - Byrne, Hannah
AU - Conroy, Paul
AU - Whisstock, James
AU - O'Kennedy, Richard
PY - 2013
Y1 - 2013
N2 - Artificial manipulation of antibody genes has facilitated the production of several unique recombinant antibody formats, which have highly important therapeutic and biotechnological applications. Although bispecific antibodies (bsAbs) are not new, they are coming to the forefront as our knowledge of the potential efficacy of antibody-based therapeutics expands. The next generation of bsAbs is developing due to significant improvements in recombinant antibody technologies. This review focuses on recent advances with a particular focus on improvements in format and design that are contributing to the resurgence of bsAbs, and in particular, on innovative structures applicable to next generation point-of-care (POC) devices with applicability to low resource environments.
AB - Artificial manipulation of antibody genes has facilitated the production of several unique recombinant antibody formats, which have highly important therapeutic and biotechnological applications. Although bispecific antibodies (bsAbs) are not new, they are coming to the forefront as our knowledge of the potential efficacy of antibody-based therapeutics expands. The next generation of bsAbs is developing due to significant improvements in recombinant antibody technologies. This review focuses on recent advances with a particular focus on improvements in format and design that are contributing to the resurgence of bsAbs, and in particular, on innovative structures applicable to next generation point-of-care (POC) devices with applicability to low resource environments.
UR - http://www.ncbi.nlm.nih.gov/pubmed/24094861
U2 - 10.1016/j.tibtech.2013.08.007
DO - 10.1016/j.tibtech.2013.08.007
M3 - Article
SN - 0167-7799
VL - 31
SP - 621
EP - 632
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 11
ER -