A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

Hannah Byrne, Paul Conroy, James Whisstock, Richard O'Kennedy

Research output: Contribution to journalArticleResearchpeer-review

115 Citations (Scopus)

Abstract

Artificial manipulation of antibody genes has facilitated the production of several unique recombinant antibody formats, which have highly important therapeutic and biotechnological applications. Although bispecific antibodies (bsAbs) are not new, they are coming to the forefront as our knowledge of the potential efficacy of antibody-based therapeutics expands. The next generation of bsAbs is developing due to significant improvements in recombinant antibody technologies. This review focuses on recent advances with a particular focus on improvements in format and design that are contributing to the resurgence of bsAbs, and in particular, on innovative structures applicable to next generation point-of-care (POC) devices with applicability to low resource environments.
Original languageEnglish
Pages (from-to)621 - 632
Number of pages12
JournalTrends in Biotechnology
Volume31
Issue number11
DOIs
Publication statusPublished - 2013

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