A T1 and DTI fused 3D Corpus Callosum analysis in pre-vs. Post-season contact sports players

Yi Lao, Meng Law, Jie Shi, Niharika Gajawelli, Lauren Haas, Yalin Wang, Natasha Leporé

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

15 Citations (Scopus)


Sports related traumatic brain injury (TBI) is a worldwide public health issue, and damage to the corpus callosum (CC) has been considered as an important indicator of TBI. However, contact sports players suffer repeated hits to the head during the course of a season even in the absence of diagnosed concussion, and less is known about their effect on callosal anatomy. In addition, T1-weighted and diffusion tensor brain magnetic resonance images (DTI) have been analyzed separately, but a joint analysis of both types of data may increase statistical power and give a more complete understanding of anatomical correlates of subclinical concussions in these athletes. Here, for the first time, we fuse T1 surface-based morphometry and a new DTI analysis on 3D surface representations of the CCs into a single statistical analysis on these subjects. Our new combined method successfully increases detection power in detecting differences between pre-vs. post-season contact sports players. Alterations are found in the ventral genu, isthmus, and splenium of CC. Our findings may inform future health assessments in contact sports players. The new method here is also the first truly multimodal diffusion and T1-weighted analysis of the CC, and may be useful to detect anatomical changes in the corpus callosum in other multimodal datasets.

Original languageEnglish
Title of host publication10th International Symposium on Medical Information Processing and Analysis
EditorsEduardo Romero, Natasha Lepore
Number of pages6
ISBN (Electronic)9781628413625
Publication statusPublished - 1 Jan 2015
Externally publishedYes
EventInternational Symposium on Medical Information Processing and Analysis 2014 - Cartagena de Indias, Colombia
Duration: 14 Oct 201416 Oct 2014
Conference number: 10th


ConferenceInternational Symposium on Medical Information Processing and Analysis 2014
Abbreviated titleSIPAIM 2014
CityCartagena de Indias
OtherThe Proceedings of SIPAIM will be published in the SPIE Digital Library (Indexed in Scopus).
Internet address

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