A Systems Approach to Understand Antigen Presentation and the Immune Response

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

The mammalian immune system has evolved to respond to pathogenic, environmental, and cellular changes in order to maintain the health of the host. These responses include the comparatively primitive innate immune response, which represents a rapid and relatively nonspecific reaction to challenge by pathogens and the more complex cellular adaptive immune response. This adaptive response evolves with the pathogenic challenge, involves the cross talk of several cell types, and is highly specific to the pathogen due to the liberation of peptide antigens and their presentation on the surface of affected cells. Together these two forms of immunity provide a surveillance mechanism for the system-wide scrutiny of cellular function, environment, and health. As such the immune system is best understood at a systems biology level, and studies that combine gene expression, protein expression, and liberation of peptides for antigen presentation can be combined to provide a detailed understanding of immunity. This chapter details our experience in identifying peptide antigens and combining this information with more traditional proteomics approaches to understand the generation of immune responses on a holistic level.
Original languageEnglish
Title of host publicationProteomics in Systems Biology
Subtitle of host publicationMethods and Protocols
EditorsJ Reinders
Place of PublicationUSA
PublisherSpringer
Pages189 - 210
Number of pages22
ISBN (Print)9781493933396
DOIs
Publication statusPublished - 2016

Cite this

Dudek, N. L., Croft, N. P., Schittenhelm, R. B., Ramarathinam, S. H., & Purcell, A. W. (2016). A Systems Approach to Understand Antigen Presentation and the Immune Response. In J. Reinders (Ed.), Proteomics in Systems Biology : Methods and Protocols (pp. 189 - 210). USA: Springer. https://doi.org/10.1007/978-1-4939-3341-9_14
Dudek, Nadine L ; Croft, Nathan P ; Schittenhelm, Ralf B ; Ramarathinam, Sri H ; Purcell, Anthony W. / A Systems Approach to Understand Antigen Presentation and the Immune Response. Proteomics in Systems Biology : Methods and Protocols. editor / J Reinders. USA : Springer, 2016. pp. 189 - 210
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Dudek, NL, Croft, NP, Schittenhelm, RB, Ramarathinam, SH & Purcell, AW 2016, A Systems Approach to Understand Antigen Presentation and the Immune Response. in J Reinders (ed.), Proteomics in Systems Biology : Methods and Protocols. Springer, USA, pp. 189 - 210. https://doi.org/10.1007/978-1-4939-3341-9_14

A Systems Approach to Understand Antigen Presentation and the Immune Response. / Dudek, Nadine L; Croft, Nathan P; Schittenhelm, Ralf B; Ramarathinam, Sri H; Purcell, Anthony W.

Proteomics in Systems Biology : Methods and Protocols. ed. / J Reinders. USA : Springer, 2016. p. 189 - 210.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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T1 - A Systems Approach to Understand Antigen Presentation and the Immune Response

AU - Dudek, Nadine L

AU - Croft, Nathan P

AU - Schittenhelm, Ralf B

AU - Ramarathinam, Sri H

AU - Purcell, Anthony W

PY - 2016

Y1 - 2016

N2 - The mammalian immune system has evolved to respond to pathogenic, environmental, and cellular changes in order to maintain the health of the host. These responses include the comparatively primitive innate immune response, which represents a rapid and relatively nonspecific reaction to challenge by pathogens and the more complex cellular adaptive immune response. This adaptive response evolves with the pathogenic challenge, involves the cross talk of several cell types, and is highly specific to the pathogen due to the liberation of peptide antigens and their presentation on the surface of affected cells. Together these two forms of immunity provide a surveillance mechanism for the system-wide scrutiny of cellular function, environment, and health. As such the immune system is best understood at a systems biology level, and studies that combine gene expression, protein expression, and liberation of peptides for antigen presentation can be combined to provide a detailed understanding of immunity. This chapter details our experience in identifying peptide antigens and combining this information with more traditional proteomics approaches to understand the generation of immune responses on a holistic level.

AB - The mammalian immune system has evolved to respond to pathogenic, environmental, and cellular changes in order to maintain the health of the host. These responses include the comparatively primitive innate immune response, which represents a rapid and relatively nonspecific reaction to challenge by pathogens and the more complex cellular adaptive immune response. This adaptive response evolves with the pathogenic challenge, involves the cross talk of several cell types, and is highly specific to the pathogen due to the liberation of peptide antigens and their presentation on the surface of affected cells. Together these two forms of immunity provide a surveillance mechanism for the system-wide scrutiny of cellular function, environment, and health. As such the immune system is best understood at a systems biology level, and studies that combine gene expression, protein expression, and liberation of peptides for antigen presentation can be combined to provide a detailed understanding of immunity. This chapter details our experience in identifying peptide antigens and combining this information with more traditional proteomics approaches to understand the generation of immune responses on a holistic level.

UR - http://www.ncbi.nlm.nih.gov/pubmed/26700050

U2 - 10.1007/978-1-4939-3341-9_14

DO - 10.1007/978-1-4939-3341-9_14

M3 - Chapter (Book)

SN - 9781493933396

SP - 189

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BT - Proteomics in Systems Biology

A2 - Reinders, J

PB - Springer

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Dudek NL, Croft NP, Schittenhelm RB, Ramarathinam SH, Purcell AW. A Systems Approach to Understand Antigen Presentation and the Immune Response. In Reinders J, editor, Proteomics in Systems Biology : Methods and Protocols. USA: Springer. 2016. p. 189 - 210 https://doi.org/10.1007/978-1-4939-3341-9_14