A sweet origin for the key congocidine precursor 4-acetamidopyrrole-2- carboxylate

Sylvie Lautru, Lijiang Song, Luc Demange, Thomas Lombès, Hervé Galons, Gregory L. Challis, Jean Luc Pernodet

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Feeding (Streptomyces) frenzy: Natural products belonging to the pyrrolamide family are defined by their pyrrole-2-carboxamide moiety. 4-acetamidopyrrole-2-carboxylate is identified as the key pyrrolamide congocidine precursor (see scheme) through feeding studies using Streptomyces ambofaciens. The biosynthetic pathway of congocidine starts with the carbohydrate N-acetylglucosamine and involves carbohydrate-processing enzymes.

Original languageEnglish
Pages (from-to)7454-7458
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number30
DOIs
Publication statusPublished - 23 Jul 2012
Externally publishedYes

Keywords

  • biosynthesis
  • congocidine
  • natural products
  • pyrrolamide
  • pyrrole

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