A supramolecular approach to the examination of the structures of some anticancer organoamidoplatinum(II) complexes

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A range of supramolecular interactions revealed on assessment of crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{(p-BrC6F4)NCH2CH2NEt2}(py)Cl], 1; [Pt{(p-HC6F4)NCH2CH2NEt2}(py)Cl], 2; [Pt{(C6F5)NCH2CH2NEt2}(py)I], 3; [Pt{(p-HC6F4)NCH2CH2NMe2}Cl(py)], 4; [Pt{(C6F5)NCH2CH2NMe2}Cl0.4I0.6(py)], 5 is examined. These interactions frequently include the axial positions above and below the coordination planes. Agostic interactions, inter- and intra-molecular H-bonding and other supramolecular interactions of all compounds were explored for a better understanding of solid state structural properties. This propensity to form a range of supramolecular interactions may assist in docking the drugs to DNA prior to coordination of DNA to these compounds.

Original languageEnglish
Pages (from-to)418-424
Number of pages7
JournalSupramolecular Chemistry
Volume30
Issue number5-6
DOIs
Publication statusPublished - 3 Jun 2018

Keywords

  • agostic
  • crystal packing
  • hydrogen bonding
  • Intermolecular interactions
  • platinum(II) complexes

Cite this

@article{a86888025e0d4d3ca3c7a9582f5d1cc4,
title = "A supramolecular approach to the examination of the structures of some anticancer organoamidoplatinum(II) complexes",
abstract = "A range of supramolecular interactions revealed on assessment of crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{(p-BrC6F4)NCH2CH2NEt2}(py)Cl], 1; [Pt{(p-HC6F4)NCH2CH2NEt2}(py)Cl], 2; [Pt{(C6F5)NCH2CH2NEt2}(py)I], 3; [Pt{(p-HC6F4)NCH2CH2NMe2}Cl(py)], 4; [Pt{(C6F5)NCH2CH2NMe2}Cl0.4I0.6(py)], 5 is examined. These interactions frequently include the axial positions above and below the coordination planes. Agostic interactions, inter- and intra-molecular H-bonding and other supramolecular interactions of all compounds were explored for a better understanding of solid state structural properties. This propensity to form a range of supramolecular interactions may assist in docking the drugs to DNA prior to coordination of DNA to these compounds.",
keywords = "agostic, crystal packing, hydrogen bonding, Intermolecular interactions, platinum(II) complexes",
author = "Ruchika Ojha and Junk, {Peter C.} and Deacon, {Glen B.} and Bond, {Alan M.}",
year = "2018",
month = "6",
day = "3",
doi = "10.1080/10610278.2017.1405003",
language = "English",
volume = "30",
pages = "418--424",
journal = "Supramolecular Chemistry",
issn = "1061-0278",
publisher = "Taylor & Francis",
number = "5-6",

}

A supramolecular approach to the examination of the structures of some anticancer organoamidoplatinum(II) complexes. / Ojha, Ruchika; Junk, Peter C.; Deacon, Glen B.; Bond, Alan M.

In: Supramolecular Chemistry, Vol. 30, No. 5-6, 03.06.2018, p. 418-424.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A supramolecular approach to the examination of the structures of some anticancer organoamidoplatinum(II) complexes

AU - Ojha, Ruchika

AU - Junk, Peter C.

AU - Deacon, Glen B.

AU - Bond, Alan M.

PY - 2018/6/3

Y1 - 2018/6/3

N2 - A range of supramolecular interactions revealed on assessment of crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{(p-BrC6F4)NCH2CH2NEt2}(py)Cl], 1; [Pt{(p-HC6F4)NCH2CH2NEt2}(py)Cl], 2; [Pt{(C6F5)NCH2CH2NEt2}(py)I], 3; [Pt{(p-HC6F4)NCH2CH2NMe2}Cl(py)], 4; [Pt{(C6F5)NCH2CH2NMe2}Cl0.4I0.6(py)], 5 is examined. These interactions frequently include the axial positions above and below the coordination planes. Agostic interactions, inter- and intra-molecular H-bonding and other supramolecular interactions of all compounds were explored for a better understanding of solid state structural properties. This propensity to form a range of supramolecular interactions may assist in docking the drugs to DNA prior to coordination of DNA to these compounds.

AB - A range of supramolecular interactions revealed on assessment of crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{(p-BrC6F4)NCH2CH2NEt2}(py)Cl], 1; [Pt{(p-HC6F4)NCH2CH2NEt2}(py)Cl], 2; [Pt{(C6F5)NCH2CH2NEt2}(py)I], 3; [Pt{(p-HC6F4)NCH2CH2NMe2}Cl(py)], 4; [Pt{(C6F5)NCH2CH2NMe2}Cl0.4I0.6(py)], 5 is examined. These interactions frequently include the axial positions above and below the coordination planes. Agostic interactions, inter- and intra-molecular H-bonding and other supramolecular interactions of all compounds were explored for a better understanding of solid state structural properties. This propensity to form a range of supramolecular interactions may assist in docking the drugs to DNA prior to coordination of DNA to these compounds.

KW - agostic

KW - crystal packing

KW - hydrogen bonding

KW - Intermolecular interactions

KW - platinum(II) complexes

UR - http://www.scopus.com/inward/record.url?scp=85037653828&partnerID=8YFLogxK

U2 - 10.1080/10610278.2017.1405003

DO - 10.1080/10610278.2017.1405003

M3 - Article

VL - 30

SP - 418

EP - 424

JO - Supramolecular Chemistry

JF - Supramolecular Chemistry

SN - 1061-0278

IS - 5-6

ER -