A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Julie Bernhardt; Kathryn S. Hayward; Numa Dancause; Natasha A. Lannin; Nick S. Ward; Randolph J. Nudo; Amanda Farrin; Leonid Churilov; Lara A. Boyd; Theresa A. Jones; S. Thomas Carmichael; Dale Corbett; Steven C. Cramer

doi:10.1177/1545968319888642

A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Julie Bernhardt, Kathryn S. Hayward, Numa Dancause, Natasha A. Lannin, Nick S. Ward, Randolph J. Nudo, Amanda Farrin, Leonid Churilov, Lara A. Boyd, Theresa A. Jones, S. Thomas Carmichael, Dale Corbett, Steven C. Cramer

Department of Neuroscience

Research output: Contribution to journal › Article › Research › peer-review

32 Citations (Scopus)

Abstract

A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.

Original language	English
Pages (from-to)	959-969
Number of pages	11
Journal	Neurorehabilitation and Neural Repair
Volume	33
Issue number	11
DOIs	https://doi.org/10.1177/1545968319888642
Publication status	Published - 1 Nov 2019

Keywords

consensus
GO NO-GO
recovery
rehabilitation
Stroke
trial design

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10.1177/1545968319888642

Cite this

Bernhardt, J., Hayward, K. S., Dancause, N., Lannin, N. A., Ward, N. S., Nudo, R. J., Farrin, A., Churilov, L., Boyd, L. A., Jones, T. A., Carmichael, S. T., Corbett, D., & Cramer, S. C. (2019). A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable. Neurorehabilitation and Neural Repair, 33(11), 959-969. https://doi.org/10.1177/1545968319888642

@article{da01e81d9abe43828d892ccb91980c5b,

title = "A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable",

abstract = "A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.",

keywords = "consensus, GO NO-GO, recovery, rehabilitation, Stroke, trial design",

author = "Julie Bernhardt and Hayward, \{Kathryn S.\} and Numa Dancause and Lannin, \{Natasha A.\} and Ward, \{Nick S.\} and Nudo, \{Randolph J.\} and Amanda Farrin and Leonid Churilov and Boyd, \{Lara A.\} and Jones, \{Theresa A.\} and Carmichael, \{S. Thomas\} and Dale Corbett and Cramer, \{Steven C.\}",

year = "2019",

month = nov,

day = "1",

doi = "10.1177/1545968319888642",

language = "English",

volume = "33",

pages = "959--969",

journal = "Neurorehabilitation and Neural Repair",

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Bernhardt, J, Hayward, KS, Dancause, N, Lannin, NA, Ward, NS, Nudo, RJ, Farrin, A, Churilov, L, Boyd, LA, Jones, TA, Carmichael, ST, Corbett, D & Cramer, SC 2019, 'A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable', Neurorehabilitation and Neural Repair, vol. 33, no. 11, pp. 959-969. https://doi.org/10.1177/1545968319888642

A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable. / Bernhardt, Julie; Hayward, Kathryn S.; Dancause, Numa et al.
In: Neurorehabilitation and Neural Repair, Vol. 33, No. 11, 01.11.2019, p. 959-969.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Nudo, Randolph J.

AU - Farrin, Amanda

AU - Churilov, Leonid

AU - Boyd, Lara A.

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AU - Carmichael, S. Thomas

AU - Corbett, Dale

AU - Cramer, Steven C.

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KW - rehabilitation

KW - Stroke

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A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Abstract

Keywords

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Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery

Cite this

A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Abstract

Keywords

Access to Document

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Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery

Cite this