A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Julie Bernhardt; Kathryn S. Hayward; Numa Dancause; Natasha A. Lannin; Nick S. Ward; Randolph J. Nudo; Amanda Farrin; Leonid Churilov; Lara A. Boyd; Theresa A. Jones; S. Thomas Carmichael; Dale Corbett; Steven C. Cramer

doi:10.1177/1747493019879657

A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Julie Bernhardt, Kathryn S. Hayward, Numa Dancause, Natasha A. Lannin, Nick S. Ward, Randolph J. Nudo, Amanda Farrin, Leonid Churilov, Lara A. Boyd, Theresa A. Jones, S. Thomas Carmichael, Dale Corbett, Steven C. Cramer

Department of Neuroscience

Research output: Contribution to journal › Article › Research › peer-review

73 Citations (Scopus)

Abstract

A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.

Original language	English
Pages (from-to)	792-802
Number of pages	11
Journal	International Journal of Stroke
Volume	14
Issue number	8
DOIs	https://doi.org/10.1177/1747493019879657
Publication status	Published - Oct 2019

Keywords

consensus
GO NO-GO
recovery
rehabilitation
Stroke
trial design

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10.1177/1747493019879657

319591522-oaFinal published version, 6.71 MB

Cite this

Bernhardt, J., Hayward, K. S., Dancause, N., Lannin, N. A., Ward, N. S., Nudo, R. J., Farrin, A., Churilov, L., Boyd, L. A., Jones, T. A., Carmichael, S. T., Corbett, D., & Cramer, S. C. (2019). A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable. International Journal of Stroke, 14(8), 792-802. https://doi.org/10.1177/1747493019879657

@article{303005b9b05a48769f686f8015cafc51,

title = "A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable",

abstract = "A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.",

keywords = "consensus, GO NO-GO, recovery, rehabilitation, Stroke, trial design",

author = "Julie Bernhardt and Hayward, {Kathryn S.} and Numa Dancause and Lannin, {Natasha A.} and Ward, {Nick S.} and Nudo, {Randolph J.} and Amanda Farrin and Leonid Churilov and Boyd, {Lara A.} and Jones, {Theresa A.} and Carmichael, {S. Thomas} and Dale Corbett and Cramer, {Steven C.}",

year = "2019",

month = oct,

doi = "10.1177/1747493019879657",

language = "English",

volume = "14",

pages = "792--802",

journal = "International Journal of Stroke",

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Bernhardt, J, Hayward, KS, Dancause, N, Lannin, NA, Ward, NS, Nudo, RJ, Farrin, A, Churilov, L, Boyd, LA, Jones, TA, Carmichael, ST, Corbett, D & Cramer, SC 2019, 'A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable', International Journal of Stroke, vol. 14, no. 8, pp. 792-802. https://doi.org/10.1177/1747493019879657

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T1 - A stroke recovery trial development framework

T2 - Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

AU - Bernhardt, Julie

AU - Hayward, Kathryn S.

AU - Dancause, Numa

AU - Lannin, Natasha A.

AU - Ward, Nick S.

AU - Nudo, Randolph J.

AU - Farrin, Amanda

AU - Churilov, Leonid

AU - Boyd, Lara A.

AU - Jones, Theresa A.

AU - Carmichael, S. Thomas

AU - Corbett, Dale

AU - Cramer, Steven C.

PY - 2019/10

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N2 - A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.

AB - A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.

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KW - recovery

KW - rehabilitation

KW - Stroke

KW - trial design

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SN - 1747-4930

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JO - International Journal of Stroke

JF - International Journal of Stroke

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ER -

A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Abstract

Keywords

Access to Document

Other files and links

Support After Stroke with group-based classeS: The SASS study

Feasibility testing of co-producing an intervention at one inpatient stroke rehabilitation unit to implement recommendations from the 2017 Stroke Clinical Guidelines

Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery

Cite this

A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Abstract

Keywords

Access to Document

Other files and links

Projects

Support After Stroke with group-based classeS: The SASS study

Feasibility testing of co-producing an intervention at one inpatient stroke rehabilitation unit to implement recommendations from the 2017 Stroke Clinical Guidelines

Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery

Cite this