Projects per year
Abstract
Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions.
Original language | English |
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Article number | 6708 |
Number of pages | 13 |
Journal | Nature Communications |
Volume | 12 |
Issue number | 1 |
DOIs | |
Publication status | Published - 18 Nov 2021 |
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Investigating a novel factor impacting stem cell development
Pocock, R. & Gopal, S.
1/01/20 → 31/12/23
Project: Research
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Role of Transient Ca2+ in Transcriptional Wiring of Stem Cells
Gopal, S., Pocock, R. & Griesbeck, O.
1/01/19 → 31/12/22
Project: Research
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CALCIUM-MEDIATED REGULATION OF STEM CELL DEVELOPMENT
Gopal, S.
Australian Research Council (ARC)
1/01/19 → 31/12/21
Project: Research