A somatic proteoglycan controls Notch-directed germ cell fate

Sandeep Gopal, Aqilah Amran, Andre Elton, Leelee Ng, Roger Pocock

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6 Citations (Scopus)


Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions.

Original languageEnglish
Article number6708
Number of pages13
JournalNature Communications
Issue number1
Publication statusPublished - 18 Nov 2021

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