A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut

Derrick K Mathias, Rebecca Pastrana-Mena, Elisabetta Ranucci, Dingyin Tao, Paolo Ferruti, Corrie Ortega, Gregory O Staples, Joseph Zaia, Eizo Takashima, Takafumi Tsuboi, Natalie Borg, Luisella Verotta, Rhoel R Dinglasan

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Malaria transmission-blocking (T-B) interventions are essential for malaria elimination. Small molecules that inhibit the Plasmodium ookinete-to-oocyst transition in the midgut of Anopheles mosquitoes, thereby blocking sporogony, represent one approach to achieving this goal. Chondroitin sulfate glycosaminoglycans (CS-GAGs) on the Anopheles gambiae midgut surface are putative ligands for Plasmodium falciparum ookinetes. We hypothesized that our synthetic polysulfonated polymer, VS1, acting as a decoy molecular mimetic of midgut CS-GAGs confers malaria T-B activity. In our study, VS1 repeatedly reduced midgut oocyst development by as much as 99 (P
Original languageEnglish
Article numbere1003757
Number of pages14
JournalPLoS Pathogens
Volume9
Issue number11
DOIs
Publication statusPublished - 2013

Cite this

Mathias, D. K., Pastrana-Mena, R., Ranucci, E., Tao, D., Ferruti, P., Ortega, C., ... Dinglasan, R. R. (2013). A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut. PLoS Pathogens, 9(11), [e1003757]. https://doi.org/10.1371/journal.ppat.1003757
Mathias, Derrick K ; Pastrana-Mena, Rebecca ; Ranucci, Elisabetta ; Tao, Dingyin ; Ferruti, Paolo ; Ortega, Corrie ; Staples, Gregory O ; Zaia, Joseph ; Takashima, Eizo ; Tsuboi, Takafumi ; Borg, Natalie ; Verotta, Luisella ; Dinglasan, Rhoel R. / A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut. In: PLoS Pathogens. 2013 ; Vol. 9, No. 11.
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abstract = "Malaria transmission-blocking (T-B) interventions are essential for malaria elimination. Small molecules that inhibit the Plasmodium ookinete-to-oocyst transition in the midgut of Anopheles mosquitoes, thereby blocking sporogony, represent one approach to achieving this goal. Chondroitin sulfate glycosaminoglycans (CS-GAGs) on the Anopheles gambiae midgut surface are putative ligands for Plasmodium falciparum ookinetes. We hypothesized that our synthetic polysulfonated polymer, VS1, acting as a decoy molecular mimetic of midgut CS-GAGs confers malaria T-B activity. In our study, VS1 repeatedly reduced midgut oocyst development by as much as 99 (P",
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Mathias, DK, Pastrana-Mena, R, Ranucci, E, Tao, D, Ferruti, P, Ortega, C, Staples, GO, Zaia, J, Takashima, E, Tsuboi, T, Borg, N, Verotta, L & Dinglasan, RR 2013, 'A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut', PLoS Pathogens, vol. 9, no. 11, e1003757. https://doi.org/10.1371/journal.ppat.1003757

A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut. / Mathias, Derrick K; Pastrana-Mena, Rebecca; Ranucci, Elisabetta; Tao, Dingyin; Ferruti, Paolo; Ortega, Corrie; Staples, Gregory O; Zaia, Joseph; Takashima, Eizo; Tsuboi, Takafumi; Borg, Natalie; Verotta, Luisella; Dinglasan, Rhoel R.

In: PLoS Pathogens, Vol. 9, No. 11, e1003757, 2013.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Mathias, Derrick K

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AU - Tao, Dingyin

AU - Ferruti, Paolo

AU - Ortega, Corrie

AU - Staples, Gregory O

AU - Zaia, Joseph

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AU - Tsuboi, Takafumi

AU - Borg, Natalie

AU - Verotta, Luisella

AU - Dinglasan, Rhoel R

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Mathias DK, Pastrana-Mena R, Ranucci E, Tao D, Ferruti P, Ortega C et al. A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut. PLoS Pathogens. 2013;9(11). e1003757. https://doi.org/10.1371/journal.ppat.1003757