A single nucleotide polymorphism -1131T>C in the apolipoprotein A5 gene modulates the levels of triglyceride

Somayyeh Haqparast, Mahdi Fasihi Ramandi, Ali Samadikuchaksaraei, Vahid Pazhakh

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Abstract

Background: The recently discovered apolipoprotein A5 (APOA5) gene has been shown to be important in determining plasma triglyceride (TG) levels, a major cardiovascular disease risk factor. We searched for possible associations of the APOA5 gene polymorphisms -1131T>C with the levels of TG in an Iranian population. Methods: A total of 128 Iranians (73 cases with coronary heart disease [CHD] and 55 normal subjects) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for this single nucleotide polymorphism. Results: Allele frequencies observed in our population were 0.152 for the C allele and 0.848 for the T allele, which are similar to Caucasian populations (P=0.355). Conclusions: As expected, we observed a strong association between the APOA5 -1131C allele and elevated plasma TG levels. Total cholesterol heterozygotes and CC homozygotes have significantly higher TG levels (2.76 ± 1.30 mmol/L) than TT homozygous individuals in the CHD group (2.05 ± 1.15 mmol/L, P=0.027). This trend was also present in the normal subjects (P=0.014).

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalLaboratory Medicine
Volume42
Issue number3
DOIs
Publication statusPublished - Mar 2011
Externally publishedYes

Keywords

  • Apolipoprotein A5
  • Coronary heart disease
  • Polymorphism
  • Triglyceride

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