A randomised controlled trial (RCT) is one of the simplest, most powerful and revolutionary tools of research. e history of clinical trial dates back to 600 B.C. when Daniel of Judah conducted what is possibly the earliest recorded clinical trial. He compared the health effects of the vegetarian diet with those of a royal Babylonian diet over a 10 day period. The trial had some missing elements by contemporary medical guidelines but the report has remained infl uential (1) The 19th century saw many major advances in clinical trials. Credit for the modern randomised trial is often given to Sir Austin Bradford Hill (2) who designed the first epidemiological study with concealment of allocation. The studya??s purpose was to determine the effect of streptomycin on pulmonary tuberculosis. Previous studies of the drug had been controlled and proved inconclusive. To settle the question Hill arranged to have the antibiotic given in some tuberculosis hospital wards but not in others. In effect, a randomised.....
|Pages (from-to)||5 - 13|
|Number of pages||9|
|Publication status||Published - 2009|