Reduced central serotonergic activity has been implicated in poor impulse regulation and aggressive behaviour in animals, adults and also young children. A polymorphism in the promoter of the serotonin transporter (5HTT) has recently been implicated in ADHD. We have examined three 5HTT polymorphisms (the promoter, the VNTR in intron 2 and the 3′ UTR SNP) in a sample of 113 ADHD trios. TDT analysis of haplotypes demonstrated significant preferential transmission of haplotypes containing the T allele of the 3′UTR SNP with the long allele of the promoter polymorphism (2 = 11.96, 3df, p 0.01) and the 10 repeat of the VNTR (2 = 10.18, 4df, P <0.05). A pooled analysis of 289 cases and 372 controls from our, and other published results for the promoter polymorphism demonstrated a significant over-representation of the long allele in ADHD probands compared to controls (2 = 7.14, P <0.01). This study provides further evidence for the possible involvement of the serotonin transporter in susceptibility to ADHD.
|Number of pages||2|
|Journal||American Journal of Medical Genetics Part B: Neuropsychiatric Genetics|
|Publication status||Published - 8 Oct 2001|