A search for the "multiple sclerosis virus"--lack of effect of brain extracts on myelin development in chickens, mice and rats.

N. R. Sims, C. C. Bernard, L. Horvath, I. R. Mackay, P. R. Carnegie

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Attempts were made to transmit possible infectious agents from tissue of MS patients into three animal species, under conditions designed to enhance the development of such an agent. Myelination was monitored by measuring CNPase activity and myelin basic protein. Although no significant effects were observed, the usefulness of a new assay for CNPase was demonstrated. Nude mice were found to have a lower level of CNPase than their heterozygous littermates.

Original languageEnglish
Pages (from-to)411-422
Number of pages12
JournalAdvances in Experimental Medicine and Biology
Volume100
Publication statusPublished - 1978

Cite this

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title = "A search for the {"}multiple sclerosis virus{"}--lack of effect of brain extracts on myelin development in chickens, mice and rats.",
abstract = "Attempts were made to transmit possible infectious agents from tissue of MS patients into three animal species, under conditions designed to enhance the development of such an agent. Myelination was monitored by measuring CNPase activity and myelin basic protein. Although no significant effects were observed, the usefulness of a new assay for CNPase was demonstrated. Nude mice were found to have a lower level of CNPase than their heterozygous littermates.",
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A search for the "multiple sclerosis virus"--lack of effect of brain extracts on myelin development in chickens, mice and rats. / Sims, N. R.; Bernard, C. C.; Horvath, L.; Mackay, I. R.; Carnegie, P. R.

In: Advances in Experimental Medicine and Biology, Vol. 100, 1978, p. 411-422.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - A search for the "multiple sclerosis virus"--lack of effect of brain extracts on myelin development in chickens, mice and rats.

AU - Sims, N. R.

AU - Bernard, C. C.

AU - Horvath, L.

AU - Mackay, I. R.

AU - Carnegie, P. R.

PY - 1978

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AB - Attempts were made to transmit possible infectious agents from tissue of MS patients into three animal species, under conditions designed to enhance the development of such an agent. Myelination was monitored by measuring CNPase activity and myelin basic protein. Although no significant effects were observed, the usefulness of a new assay for CNPase was demonstrated. Nude mice were found to have a lower level of CNPase than their heterozygous littermates.

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M3 - Article

VL - 100

SP - 411

EP - 422

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -