A review of pathophysiology and current treatment for neonatal alloimmune thrombocytopenia (NAIT) and introducing the Australian NAIT registry

Fetomaternal or neonatal alloimmune thrombocytopenia (NAIT) is a rare but serious condition associated with significant fetal and neonatal morbidity and mortality. In this article, we highlight the current understanding of the pathophysiology of NAIT and review present approaches to investigation and management. We also introduce the new Australian NAIT Registry. Owing to the relative rarity of NAIT1 and the difficulty in accruing sufficient patient numbers for studies and clinical trials at an institutional level, this national registry will provide valuable information and inform future research on this condition.