TY - JOUR
T1 - A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L.
AU - Hossain, Md Sanower
AU - Sharfaraz, Ashik
AU - Dutta, Amit
AU - Ahsan, Asif
AU - Masud, Md Anwarul
AU - Ahmed, Idris Adewale
AU - Goh, Bey Hing
AU - Urbi, Zannat
AU - Sarker, Md Moklesur Rahman
AU - Ming, Long Chiau
N1 - Funding Information:
Authors are grateful to Rabyea Jahan Mukti for her artwork (Fig. 1) included in this study which added a great value in understanding the Nigella sativa's anatomy.
Publisher Copyright:
© 2021 The Authors
PY - 2021/11
Y1 - 2021/11
N2 - Nigella sativa L. is one of the most extensively used traditional medicinal plants. This widely studied plant is known to display diverse pharmacological actions, including antimicrobial activities. Current literature has documented its multi-target mode of antimicrobial actions. N. sativa or its bioactive compounds, such as thymoquinone, can induce oxidative stress, cell apoptosis (by producing reactive oxygen species), increase membrane permeability, inhibit efflux pumps, and impose strong biocidal actions. Despite its well-documented antimicrobial efficacy in the experimental model, to the best of our knowledge its antimicrobial mechanisms highlighting the multi-targeting properties have yet to be well discussed. Is N. sativa or thymoquinone a valuable lead compound for therapeutic development for infectious diseases? Are N. sativa's bioactive compounds potential antimicrobial agents or able to overcome antimicrobial resistance? This review aims to discuss the antimicrobial pharmacology of N. sativa-based treatments. Additionally, it provides a holistic overview of the ethnobotany, ethnopharmacology, and phytochemistry of N. sativa.
AB - Nigella sativa L. is one of the most extensively used traditional medicinal plants. This widely studied plant is known to display diverse pharmacological actions, including antimicrobial activities. Current literature has documented its multi-target mode of antimicrobial actions. N. sativa or its bioactive compounds, such as thymoquinone, can induce oxidative stress, cell apoptosis (by producing reactive oxygen species), increase membrane permeability, inhibit efflux pumps, and impose strong biocidal actions. Despite its well-documented antimicrobial efficacy in the experimental model, to the best of our knowledge its antimicrobial mechanisms highlighting the multi-targeting properties have yet to be well discussed. Is N. sativa or thymoquinone a valuable lead compound for therapeutic development for infectious diseases? Are N. sativa's bioactive compounds potential antimicrobial agents or able to overcome antimicrobial resistance? This review aims to discuss the antimicrobial pharmacology of N. sativa-based treatments. Additionally, it provides a holistic overview of the ethnobotany, ethnopharmacology, and phytochemistry of N. sativa.
KW - Antibacterial agent
KW - Antibiotic resistance
KW - Bioactive molecules
KW - Medicinal plant
KW - Natural products
KW - PhytochemistryToxicology
UR - http://www.scopus.com/inward/record.url?scp=85116074169&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2021.112182
DO - 10.1016/j.biopha.2021.112182
M3 - Review Article
C2 - 34649338
AN - SCOPUS:85116074169
VL - 143
JO - Biomedicine & Pharmacotherapy
JF - Biomedicine & Pharmacotherapy
SN - 0753-3322
M1 - 112182
ER -
