A repetitive antigen of Plasmodium falciparum that is homologous to heat shock protein 70 of Drosophila melanogaster

A. E. Bianco, J. M. Favaloro, T. R. Burkot, J. G. Culvenor, P. E. Crewther, G. V. Brown, R. F. Anders, R. L. Coppel, D. J. Kemp

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Abstract

We describe an antigen of Plasmodium falciparum, defined by a cDNA clone designated Ag63. The antigen is an abundant, soluble cytoplasmic polypeptide of M(r) 75,000 present in all stages of asexual development in the blood and in gametocytes, but not in sporozoites. The sequence of the cDNA clone revealed that, like many other antigens of P. falciparum, it contains tandemly repeated amino acid sequences, in this case Gly-Gly-Met-Pro. However, the rest of the sequence is 70% homologous at the amino acid level to the heat shock protein hsp70 of Drosophila melanogaster.

Original languageEnglish
Pages (from-to)8713-8717
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number22
DOIs
Publication statusPublished - 1 Dec 1986
Externally publishedYes

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