A relacao entre o transtorno obsessivo-compulsivo e a epilepsia. Serie psicofarmacologia - 79

Translated title of the contribution: The relationship between obsessive-compulsive disorder and epilepsy

Leonardo Fontenelle, Carla Marques, Roberto A. Piedade, Ivan Figueira, Antônio Egídio Nardi, Márcio Versiani

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)


Objective: To study the relationship between obsessive-compulsive disorder (O.C.D.) and epilepsy. Methods: Review of cases reports of patients with O.C.D. and epilepsy and patients with O.C.D. and convulsions related to E.C.T. or to psychotropic medications. This was made through a MEDLINE search (keywords: obsessive-compulsive and epilepsy, obsessive-compulsive and seizure(s), obsessive-compulsive and fit(s), obsessive-compulsive and electroconvulsive therapy (E.C.T.) and review of the bibliography of articles and related books (Jakes, 1996; Yaryura-Tobias e Neziroglu, 1997; Jenike, Baer, Minichiello, 1998). Results: Interictal obsessive-compulsive symptoms (interictal O.C.S.) seems to be more common in children and adolescents and to take place just after the beginning of Epilepsy. Ictal automatisms can be phenomenologically similar to obsessive-compulsive symptoms ('Ictal O.C.S.'). The interictal O.C.S. can also take place in the post-ictal period. It's possible that the comorbidity of O.C.S. and epilepsy is a reflex of a common cerebral dysfunction. Anticonvulsant treatment can control O.C.S. and epilepsy. Electroconvulsive therapy seems to decrease O.C.S. only in patients with primary O.C.D. and depressive symptoms or O.C.S. secondary to depression (but not in patients with primary O.C.D. without depressive symptoms). Conclusions: The comorbidity of O.C.D. and epilepsy can allow a better knowledge of neurobiology of primary O.C.D. Patients with O.C.S. and epilepsy can benefit from a differential clinical approach.

Translated title of the contributionThe relationship between obsessive-compulsive disorder and epilepsy
Original languagePortuguese
Pages (from-to)591-598
Number of pages8
JournalJornal Brasileiro de Psiquiatria
Issue number11
Publication statusPublished - 1 Nov 1998
Externally publishedYes


  • Electroconvulsive therapy
  • Epilepsy
  • Obsessive-compulsive disorder
  • Seizures

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