Abstract
Revealing the hidden mechanism of how cells sense and react to environmental signals has been a central question in cell biology. We focused on the rate of increase of stimulation, or temporal gradient, known to cause different responses of cells. We have investigated all possible three-node enzymatic networks and identified a network motif that robustly generates a transient or sustained response by acute or gradual stimulation, respectively. We also found that a regulated double-negative feedback within the motif is essential for the temporal gradient-sensitive switching. Our analysis highlights the essential structure and mechanism enabling cells to properly respond to dynamic environmental changes.
Original language | English |
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Article number | 0162153 |
Number of pages | 17 |
Journal | PLoS ONE |
Volume | 11 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Sep 2016 |
Keywords
- network motiffs
- signaling networks
- signal processing
- feedback regulation
- enzyme regulation
- enzymes
- hormone receptor signaling
- ERK signaling cascade