Abstract
Objective: To determine whether the use of heated-humidified gases for respiratory support during the stabilization of infants <30 weeks of gestational age (GA) in the delivery room reduces rates of hypothermia on admission to the neonatal intensive care unit (NICU). Study design: A multicenter, unblinded, randomized trial was conducted in Melbourne, Australia, between February 2013 and June 2015. Infants <30 weeks of GA were randomly assigned to receive either heated-humidified gases or unconditioned gases during stabilization in the delivery room and during transport to NICU. Infants born to mothers with pyrexia >38°C were excluded. Primary outcome was rate of hypothermia on NICU admission (rectal temperature <36.5°C). Results: A total of 273 infants were enrolled. Fewer infants in the heated-humidified group were hypothermic on admission to NICU (36/132 [27%]) compared with controls (61/141 [43%], P <.01). There was no difference in rates of hyperthermia (>37.5°C); 20% (27/132) in the heated-humidified group compared with 16% (22/141) in the controls (P =.30). There were no differences in mortality or respiratory outcomes. Conclusions: The use of heated-humidified gases in the delivery room significantly reduces hypothermia on admission to NICU in preterm infants, without increased risk of hyperthermia. Clinical Trial Registration: Australian and New Zealand Clinical Trials Register (www.anzctr.org.au) ACTRN12613000093785.
Original language | English |
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Pages (from-to) | 47-53 |
Number of pages | 7 |
Journal | The Journal of Pediatrics |
Volume | 193 |
DOIs | |
Publication status | Published - 1 Feb 2018 |
Keywords
- delivery room
- gas conditioning
- humidification
- hypothermia
- newborn resuscitation
- newborn stabilization
- respiratory support