A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1

Anthony D. Kelleher, Rebekah L. Puls, Mark Bebbington, David Boyle, Rosemary Ffrench, Stephen J. Kent, Sue Kippax, Damian F.J. Purcell, Scott Thomson, Handan Wand, David A. Cooper, Sean Emery

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Abstract

An HIV-vaccine consisting of a DNA prime, recombinant fowlpox virus (rFPV) boost was evaluated in a double-blind placebo controlled trial. One milligram of pHIS-HIV-B expressing mutated gag, pol, env, vpu, tat and rev was administered at weeks 0 and 4 boosted by 5 × 107 pfu rFPV-HIV-B expressing gag/pol at week 8. The vaccine regimen was safe, but there was no difference between vaccine (n = 18) and placebo recipients (n = 6) for Gag or Pol-specific T-cell immune responses at week 9.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalAIDS
Volume20
Issue number2
DOIs
Publication statusPublished - 1 Jan 2006

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