Une étude randomisée contrôlée de la capacité du Plasma-Lyte® intraveineux en volume élevé ou faible pour prévenir l’hypotension pendant la sédation pour colonoscopie

Translated title of the contribution: A randomized-controlled trial of high- or low-volume intravenous Plasma-Lyte® to prevent hypotension during sedation for colonoscopy

Kate Leslie, Megan Allen, Austin Lee, Phillip Clarke

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to compare the incidence of hypotension during sedation in adults presenting for elective colonoscopy and randomized to intravenous Plasma-Lyte 148® at either 2 mL·kg−1 (low volume) or 20 mL·kg−1 (high volume). Methods: Patients aged ≥ 18 yr presenting for elective colonoscopy, with or without gastroscopy, after oral bowel preparation were randomized to receive the intervention immediately before the start of the procedure. Hypotension was defined as a ≥ 25% decrease in systolic blood pressure (SBP) from baseline during the procedure. Secondary outcomes included SBP < 90 mmHg, lowest SBP during sedation, duration of hypotension, use of vasopressors, postoperative outcomes, and cost. Results: Seventy-five patients were randomly allocated to either the low-volume or high-volume group, respectively (total n = 150). The incidence of hypotension was similar in the two groups (59% vs 56%, respectively; odds ratio, 0.90; 95% confidence interval, 0.47 to 1.71; P = 0.74). The incidence of SBP < 90 mmHg, the lowest SBP during sedation, the duration of hypotension, the use of vasopressors, and postoperative outcomes were also similar in the two groups. Conclusions: This study does not support the routine use of 20 mL·kg−1 of intravenous Plasma-Lyte 148 to prevent hypotension and other complications during sedation for elective colonoscopy in adult patients. Clinical Trials Registry (ANZCTR 12615001288516).

Translated title of the contributionA randomized-controlled trial of high- or low-volume intravenous Plasma-Lyte® to prevent hypotension during sedation for colonoscopy
Original languageFrench
Pages (from-to)952-961
Number of pages10
JournalCanadian Journal of Anesthesia
Volume63
Issue number8
DOIs
Publication statusPublished - 1 Aug 2016

Cite this